Malaisse W J
Arch Int Pharmacodyn Ther. 1977 Aug;228(2):339-44.
Suloctidil (0.5 to 5.0 micrometer) inhibits insulin release evoked by glucose or alpha-ketoisocaproate in pancreatic islets. The drug also inhibits basal and glucose-stimulated 45calcium net uptake by the islets. In an artificial system, suloctidil inhibits A23187-mediated calcium translocation. It is proposed that the inhibitory action of suloctidil upon islet function may be due to interference with B-cell native ionophoretic system(s).
舒洛地尔（0.5至5.0微米）可抑制胰岛中葡萄糖或α-酮异己酸诱发的胰岛素释放。该药物还可抑制胰岛对基础和葡萄糖刺激的45钙的净摄取。在人工系统中，舒洛地尔可抑制A23187介导的钙转运。有人提出，舒洛地尔对胰岛功能的抑制作用可能是由于干扰了B细胞天然离子载体系统。
