Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
McGill Vision Research Unit, Department of Ophthalmology, McGill University, Montreal, Quebec, Canada.
Invest Ophthalmol Vis Sci. 2021 Feb 1;62(2):23. doi: 10.1167/iovs.62.2.23.
Amblyopes suffer a defect in temporal processing, presumably because of a neural delay in their visual processing. By measuring flash-lag effect (FLE), we investigate whether the amblyopic visual system could compensate for the intrinsic neural delay due to visual information transmissions from the retina to the cortex.
Eleven adults with amblyopia and 11 controls with normal vision participated in this study. We assessed the monocular FLE magnitude for each subject by using a typical FLE paradigm: a bar moved horizontally, while a flashed bar briefly appeared above or below it. Three luminance contrasts of the flashed bar were tested: 0.2, 0.6, and 1.
All participants, controls and those with amblyopia, showed a typical FLE. However, the FLE magnitude of participants with amblyopia was significantly shorter than that of the control participants, for both their amblyopic eye (AE) and fellow eye (FE). A nonsignificant difference was found in FLE magnitude between the AE and the FE.
We demonstrate a reduced FLE both in the AE as well as the FE of patients with amblyopia, suggesting a global visual processing deficit. We suggest it may be attributed to a more limited spatiotemporal extent of facilitatory anticipatory activity within the amblyopic primary visual cortex.
弱视患者存在时间处理缺陷，推测是由于视觉处理中的神经延迟所致。通过测量闪光滞后效应（FLE），我们研究弱视视觉系统是否可以补偿由于视觉信息从视网膜传输到皮层而导致的固有神经延迟。
11 名弱视成年人和 11 名视力正常的对照者参加了这项研究。我们使用典型的 FLE 范式评估了每个受试者的单眼 FLE 幅度：一个条形物体水平移动，同时一个闪烁的条形物短暂出现在其上方或下方。测试了三个闪烁条的亮度对比度：0.2、0.6 和 1。
所有参与者，包括弱视者和对照组，均表现出典型的 FLE。然而，弱视者的 FLE 幅度明显短于对照组，无论是他们的弱视眼（AE）还是对侧眼（FE）。AE 和 FE 之间的 FLE 幅度没有显著差异。
我们在弱视患者的 AE 和 FE 中均显示出降低的 FLE，表明存在整体视觉处理缺陷。我们认为，这可能归因于弱视初级视觉皮层内促进性预期活动的空间和时间范围更有限。
