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本文引用的文献

1
Cost effectiveness of caplacizumab in acquired thrombotic thrombocytopenic purpura.卡泊西单抗治疗获得性血栓性血小板减少性紫癜的成本效益
Blood. 2021 Feb 18;137(7):969-976. doi: 10.1182/blood.2020006052.
2
ISTH guidelines for treatment of thrombotic thrombocytopenic purpura.国际血栓与止血学会（ISTH）血栓性血小板减少性紫癜治疗指南。
J Thromb Haemost. 2020 Oct;18(10):2496-2502. doi: 10.1111/jth.15010. Epub 2020 Sep 11.
3
ADAMTS13 and VWF activities guide individualized caplacizumab treatment in patients with aTTP.ADAMTS13 和 VWF 活性指导 aTTP 患者个体化的卡普拉珠单抗治疗。
Blood Adv. 2020 Jul 14;4(13):3093-3101. doi: 10.1182/bloodadvances.2020001987.
4
The high cost of prescription drugs: causes and solutions.处方药的高昂成本：成因与解决方案。
Blood Cancer J. 2020 Jun 23;10(6):71. doi: 10.1038/s41408-020-0338-x.
5
How targeted therapy disrupts the treatment paradigm for acquired TTP: the risks, benefits, and unknowns.靶向治疗如何打破获得性 TTP 的治疗模式：风险、获益和未知。
Blood. 2019 Aug 1;134(5):415-420. doi: 10.1182/blood.2019000954. Epub 2019 Jun 19.
6
Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura.卡普拉珠单抗治疗获得性血栓性血小板减少性紫癜。
N Engl J Med. 2019 Jan 24;380(4):335-346. doi: 10.1056/NEJMoa1806311. Epub 2019 Jan 9.
7
TTP: long-term outcomes following recovery.TTP：恢复后的长期预后。
Hematology Am Soc Hematol Educ Program. 2018 Nov 30;2018(1):548-552. doi: 10.1182/asheducation-2018.1.548.
8
Caplacizumab reduces the frequency of major thromboembolic events, exacerbations and death in patients with acquired thrombotic thrombocytopenic purpura.卡普雷珠单抗可降低获得性血栓性血小板减少性紫癜患者的主要血栓栓塞事件、恶化事件和死亡的发生频率。
J Thromb Haemost. 2017 Jul;15(7):1448-1452. doi: 10.1111/jth.13716. Epub 2017 Jun 5.
9
Development and validation of a predictive model for death in acquired severe ADAMTS13 deficiency-associated idiopathic thrombotic thrombocytopenic purpura: the French TMA Reference Center experience.获得性严重 ADAMTS13 缺乏相关性特发性血栓性血小板减少性紫癜死亡预测模型的建立和验证：法国 TMA 参考中心经验。
Haematologica. 2012 Aug;97(8):1181-6. doi: 10.3324/haematol.2011.049676. Epub 2012 May 11.

计算卡帕单抗的成本。

Counting the cost of caplacizumab.

作者信息

Chaturvedi Shruti

机构信息

Johns Hopkins University School of Medicine.

出版信息

Blood. 2021 Feb 18;137(7):871-872. doi: 10.1182/blood.2020009250.

DOI:10.1182/blood.2020009250
PMID:33599760
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7918185/
Abstract

In this issue of Goshua et al present a timely cost-effectiveness analysis of caplacizumab for immune thrombotic thrombocytopenic purpura (iTTP) and conclude that adding caplacizumab to standard-of-care (SOC) therapy with plasma exchange and immunosuppression is not cost-effective based on outcomes including duration of hospitalization and iTTP recurrence.

摘要

在本期杂志中，戈舒阿等人针对卡泊单抗治疗免疫性血栓性血小板减少性紫癜（iTTP）进行了及时的成本效益分析，并得出结论：基于包括住院时间和iTTP复发等结果，在采用血浆置换和免疫抑制的标准治疗（SOC）方案中添加卡泊单抗并不具有成本效益。