Department of Otolaryngology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
Department of Otolaryngology, Peking University Third Hospital, Peking University, 49 North Huayuan Road, Beijing, 100191, China.
Eur Arch Otorhinolaryngol. 2021 Nov;278(11):4469-4476. doi: 10.1007/s00405-021-06675-y. Epub 2021 Feb 18.
Current population-based estimates of the incidence and prognosis of lung metastases of hypopharyngeal cancer are lacking. The purpose of the study is to characterize the incidence proportions and survival probability of patients with hypopharyngeal cancer and lung metastases.
We identified 2714 adult patients diagnosed with hypopharyngeal cancer between 2010 and 2014 for whom the status of lung metastases was known from the SEER database. Multivariable logistic and Cox regression models were performed to identify the risk factors associated with the presence of lung metastases at diagnosis and 5-year all-cause mortality, respectively.
We identified 128 patients with lung metastases at the time of diagnosis of hypopharyngeal cancer. Females were less likely to have lung metastases. Incidences of lung metastases were higher among patients with histological grade III/IV. For each 10 mm increase in tumor size, the odds of having lung metastases increased by 6.6%. Patients with lung metastases had a shorter survival time.
Our study provides insight into the epidemiology of lung metastases in patients with hypopharyngeal cancer. When the tumor is diagnosed, we should pay close attention to the sex, race, tumor size and histological grade to quickly detect the distant metastases.
目前缺乏基于人群的下咽癌肺转移发生率和预后的估计。本研究旨在描述下咽癌合并肺转移患者的比例和生存概率。
我们从 SEER 数据库中确定了 2010 年至 2014 年间诊断为下咽癌的 2714 名成年患者，其中已知肺转移状态。采用多变量逻辑回归和 Cox 回归模型分别确定与诊断时存在肺转移和 5 年全因死亡率相关的危险因素。
我们在诊断下咽癌时发现了 128 例肺转移患者。女性发生肺转移的可能性较小。组织学分级 III/IV 级的患者肺转移发生率较高。肿瘤大小每增加 10mm，发生肺转移的几率增加 6.6%。发生肺转移的患者生存时间更短。
本研究深入了解了下咽癌患者肺转移的流行病学。在诊断肿瘤时，我们应密切关注性别、种族、肿瘤大小和组织学分级，以便快速发现远处转移。
