Marseille North University Hospital, chemin des Bourrely, Marseille, France.
Retina. 2021 Mar 1;41(3):563-571. doi: 10.1097/IAE.0000000000002886.
To compare pseudocolor Optos ultrawidefield (UWF) retinal images with conventional real-color fundus photography (CFP) for detecting macular hyperpigmentary changes in intermediate age-related macular degeneration.
This retrospective study included 50 patients diagnosed with intermediate age-related macular degeneration. All patients underwent Optos imaging and CFP. The overall accuracy to visualize hyperpigmentation and its morphologic features was graded by two independent readers using a standardized grid. Structural and en face optical coherence tomography images were correlated with UWF and CFP images to determine spatial correspondence of pigment clumping on fundus images and hyperreflective foci on optical coherence tomography.
One hundred eyes of 50 patients had hyperpigmentary changes on funduscopic examination and were included. The intragraders and intergraders agreements were high for all measurements (P < 0.001). At least one hyperpigmentary changes within the standardized grid was detected in 93% using CFP and 100% using UWF camera (P = 0.02). The total area of hyperpigmentation measured on UWF images was significantly higher than on CFP images (P < 0.001). There was a significant correlation between the presence of hyperpigmentary changes on both CFP and UWF images and hyperreflective foci on structural optical coherence tomography (P < 0.001).
Ultrawidefield fundus images allow high detection and accurate quantification of macular hyperpigmentary changes in intermediate age-related macular degeneration compared with conventional CFP.
比较假彩色 Optos 超广角（UWF）视网膜图像与传统的眼底彩色照相（CFP）检测中间型年龄相关性黄斑变性的黄斑色素变化。
这项回顾性研究纳入了 50 名被诊断为中间型年龄相关性黄斑变性的患者。所有患者均接受了 Optos 成像和 CFP 检查。两位独立的读者使用标准化网格对观察到的色素沉着和其形态特征的整体准确性进行分级。结构和共焦光学相干断层扫描图像与 UWF 和 CFP 图像相关联，以确定眼底图像上色素团块和光学相干断层扫描上高反射焦点的空间对应关系。
眼底镜检查发现 50 例患者中有 100 只眼有色素沉着改变，将其纳入研究。所有测量的组内和组间一致性均很高（P<0.001）。使用 CFP 可检测到标准化网格内至少一处色素沉着改变的比例为 93%，而使用 UWF 相机则为 100%（P=0.02）。UWF 图像上测量的色素沉着总面积明显高于 CFP 图像（P<0.001）。CFP 和 UWF 图像上均存在色素沉着改变与结构光学相干断层扫描上的高反射焦点之间存在显著相关性（P<0.001）。
与传统的 CFP 相比，超广角眼底图像可更准确地检测和定量分析中间型年龄相关性黄斑变性的黄斑色素变化。
