中心凹无血管区容积：基于光相干断层扫描血管造影图像的新指标。

FOVEAL AVASCULAR ZONE VOLUME: A New Index Based on Optical Coherence Tomography Angiography Images.

机构信息

School of Computer Science and Engineering, Nanjing University of Science and Technology, Nanjing, China ; and.

Department of Ophthalmology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China .

出版信息

Retina. 2021 Mar 1;41(3):595-601. doi: 10.1097/IAE.0000000000002890.

DOI:10.1097/IAE.0000000000002890

PMID:33600135

Abstract

PURPOSE

To propose a new clinical evaluation index, foveal avascular zone (FAZ) volume, and analyze its statistical significance.

METHODS

A semiautomatic method is proposed to measure the FAZ volume in optical coherence tomography angiography images as follows: The region of interest was flattened and annotated axially. The labeled pixels in the restored region of interest were counted as the FAZ volume. Linear regression and the independent samples t-test were performed for the statistical analysis.

RESULTS

Sixty-one normal, 64 high myopia, and 42 diabetic retinopathy eyes were imaged using optical coherence tomography angiography. For normal eyes, the FAZ volume correlates inversely with central macular thickness (superficial: P = 0.004; deep: P < 0.001) and positively with area (P < 0.001). For high myopia eyes, the deep plexus FAZ (P = 0.34) and total FAZ (P = 0.38) volumes show no significant difference, whereas the superficial plexus FAZ volume is significantly larger than control (P < 0.001). For diabetic retinopathy eyes, the superficial plexus FAZ (P = 0.001), deep plexus FAZ (P = 0.014), and total volumes (P = 0.002) are significantly larger than control.

CONCLUSION

The FAZ volume is proposed for depicting the 3D structure of the FAZ. It shows greater sensitivity for vascular alteration that makes it meaningful for clinical analysis.

摘要

目的

提出一种新的临床评估指标——中心凹无血管区（FAZ）体积，并分析其统计学意义。

方法

提出一种半自动方法来测量光学相干断层扫描血管造影图像中的 FAZ 体积，如下所示：将感兴趣区域展平并轴向注释。将恢复的感兴趣区域中的标记像素计数为 FAZ 体积。进行线性回归和独立样本 t 检验进行统计分析。

结果

对 61 只正常眼、64 只高度近视眼和 42 只糖尿病性视网膜病变眼进行了光学相干断层扫描血管造影成像。对于正常眼，FAZ 体积与黄斑中心厚度呈负相关（浅层：P = 0.004；深层：P < 0.001），与面积呈正相关（P < 0.001）。对于高度近视眼，深层丛 FAZ（P = 0.34）和总 FAZ（P = 0.38）体积无显著差异，而浅层丛 FAZ 体积明显大于对照组（P < 0.001）。对于糖尿病性视网膜病变眼，浅层丛 FAZ（P = 0.001）、深层丛 FAZ（P = 0.014）和总体积（P = 0.002）均明显大于对照组。