Günther W, Günther R, Streck P, Römig H, Rödel A
Psychiatrische Universitätsklinik, München, Federal Republic of Germany.
Eur Arch Psychiatry Neurol Sci. 1988;237(2):65-73. doi: 10.1007/BF00382369.
This study investigates the presence and course of motor symptoms in endogenous (n = 42) and non-endogenous (n = 15) depressed patients (both medicated and unmedicated) in comparison to 15 healthy control persons. As in our previous studies on schizophrenic and depressed patients, we used a motor test battery, which consisted of the Motorische Leistungsserie, a modified version of the Lincoln Oseretzky Motor Development Scale and the motor subtest of the Luria Nebraska Neuropsychological Battery. Previous findings had suggested the existence of a psychotic motor syndrome (PMS) in endogenous depressed patients (and schizophrenics), involving disturbances of the lips and tongue, fine and gross movements of the dominant right hand and the complex motor coordination of the extremities. We re-confirmed the PMS in acute endogenous depressed patients, both medicated and unmedicated. Such a motor syndrome did not exist in healthy controls, or in non-endogenous depressed patients, irrespective of the severity of the depressive syndrome. This PMS showed a clear improvement with the amelioration of the depressive symptoms in endogenous depressed patients towards the end of the hospital treatment period and disappeared entirely in patients in a symptom free interval. This may be suggestive of a possible role for the PMS as a state marker for endogenous depression, in contrast to the persistence of the PMS in schizophrenics (trait marker), described previously. The results of factorial analyses on motor performance did not reveal differences in the factorial structure between depressives, schizophrenics and normals. However, they indicated disturbances on a general motor factor, which may account for the performance deficits in psychotic patients.(ABSTRACT TRUNCATED AT 250 WORDS)
本研究调查了内源性抑郁患者（n = 42）和非内源性抑郁患者（n = 15）（包括服药和未服药者）运动症状的存在情况及病程，并与15名健康对照者进行比较。正如我们之前对精神分裂症患者和抑郁患者的研究一样，我们使用了一套运动测试组合，其中包括运动能力系列测试、林肯 - 奥谢茨基运动发展量表的修订版以及鲁利亚 - 内布拉斯加神经心理成套测验的运动子测验。先前的研究结果表明，内源性抑郁患者（以及精神分裂症患者）存在一种精神病性运动综合征（PMS），涉及嘴唇和舌头的功能障碍、优势右手的精细和粗大运动以及四肢的复杂运动协调。我们再次证实了急性内源性抑郁患者（无论是否服药）存在PMS。健康对照者或非内源性抑郁患者中不存在这种运动综合征，无论抑郁综合征的严重程度如何。这种PMS在内源性抑郁患者的抑郁症状在住院治疗末期有所改善时明显改善，并在症状缓解期的患者中完全消失。这可能表明PMS作为内源性抑郁的一种状态标志物具有潜在作用，这与先前描述的精神分裂症患者中PMS的持续性（特质标志物）形成对比。运动表现的因子分析结果未显示抑郁患者、精神分裂症患者和正常人在因子结构上存在差异。然而，这些结果表明存在一个一般运动因子的功能障碍，这可能解释了精神病患者的表现缺陷。（摘要截选至250字）
