Q-立方突变体提示 CLC 反向转运机制的线索。
Q-cubed mutant cues clues to CLC antiport mechanism.
机构信息
Department of Biochemistry, Brandeis University, Waltham, MA.
出版信息
J Gen Physiol. 2021 Apr 5;153(4). doi: 10.1085/jgp.202112868.
Abstract
A new structure of a CLC antiporter mutant, along with EPR spectroscopy and computational dynamics, now resolves several basic puzzles regarding how these transporters stoichiometrically move Cl and H in opposite directions across biological membranes.
摘要
一种新型 CLC 阴离子转运体突变体结构，结合电子顺磁共振波谱学和计算动力学，解决了这些转运体如何在生物膜上协同地将 Cl 和 H 沿相反方向转运的几个基本难题。
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