西洛他唑和普罗布考治疗卒中后认知功能减退：PICASSO试验的认知结局子研究 - Suppr

Cilostazol and Probucol for Cognitive Decline after Stroke: A Cognitive Outcome Substudy of the PICASSO Trial.

作者信息

Lim Jae-Sung, Kwon Sun U, Yu Kyung-Ho, Yu Sungwook, Park Jong-Ho, Lee Byung-Chul, Oh Mi Sun, Kim Yong-Jae, Rha Joung-Ho, Hwang Yang-Ha, Lee Ji Sung, Heo Sung Hyuk, Ahn Seong Hwan, Seo Woo-Keun, Park Jong-Moo, Lee Ju-Hun, Kwon Jee-Hyun, Sohn Sung-Il, Jung Jin-Man, Kim Hahn Young, Kim Eung-Gyu, Cha Jae-Kwan, Park Man-Seok, Nam Hyo Suk, Bae Hee-Joon, Kim Dong-Eog, Park Jaeseol, Kang Yeonwook, Choi Jimi, Lee Juneyoung

机构信息

Department of Neurology, Hallym University Sacred Heart Hospital, Hallym Neurological Institute, Hallym University College of Medicine, Anyang, Korea.

Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

出版信息

J Stroke. 2021 Jan;23(1):128-131. doi: 10.5853/jos.2020.03650. Epub 2021 Jan 31.

DOI:10.5853/jos.2020.03650

PMID:33600710

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7900397/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01cc/7900397/5ad2743e922d/jos-2020-03650f1.jpg

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Cilostazol and Probucol for Cognitive Decline after Stroke: A Cognitive Outcome Substudy of the PICASSO Trial.西洛他唑和普罗布考治疗卒中后认知功能减退：PICASSO试验的认知结局子研究

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Clin Ther. 2009 Oct;31(10):2098-106. doi: 10.1016/j.clinthera.2009.10.005.

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Prevention of cardiovascular events in Asian patients with ischaemic stroke at high risk of cerebral haemorrhage (PICASSO): a multicentre, randomised controlled trial.亚洲缺血性脑卒中高危脑出血风险患者的心血管事件预防（PICASSO）：一项多中心、随机对照试验。

Lancet Neurol. 2018 Jun;17(6):509-518. doi: 10.1016/S1474-4422(18)30128-5.

STROKOG (stroke and cognition consortium): An international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease.STROKOG（卒中与认知联盟）：一个旨在研究与脑血管疾病相关的神经认知障碍的流行病学、诊断和治疗的国际联盟。

Alzheimers Dement (Amst). 2016 Nov 18;7:11-23. doi: 10.1016/j.dadm.2016.10.006. eCollection 2017.

Design and Rationale for a Cognitive Outcome Substudy in Ischemic Stroke Patients with High Risk of Cerebral Hemorrhage.脑出血高危缺血性脑卒中患者认知结局子研究的设计与原理

J Stroke Cerebrovasc Dis. 2016 Aug;25(8):2061-6. doi: 10.1016/j.jstrokecerebrovasdis.2016.04.028. Epub 2016 Jun 1.

Effects of long-term blood pressure lowering and dual antiplatelet treatment on cognitive function in patients with recent lacunar stroke: a secondary analysis from the SPS3 randomised trial.近期腔隙性卒中患者长期降压和双联抗血小板治疗对认知功能的影响：来自 SPS3 随机试验的二次分析。

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Cilostazol add-on therapy in patients with mild dementia receiving donepezil: a retrospective study.在接受多奈哌齐治疗的轻度痴呆患者中使用西洛他唑附加疗法：一项回顾性研究。

PLoS One. 2014 Feb 26;9(2):e89516. doi: 10.1371/journal.pone.0089516. eCollection 2014.

Cognitive impairment in lacunar strokes: the SPS3 trial.腔隙性卒中患者的认知功能障碍：SPS3 试验。

Ann Neurol. 2012 Sep;72(3):351-62. doi: 10.1002/ana.23733.

Probucol, a lipid-lowering drug, prevents cognitive and hippocampal synaptic impairments induced by amyloid β peptide in mice.普罗布考，一种降脂药物，可预防淀粉样β肽在小鼠体内引起的认知和海马突触损伤。

Exp Neurol. 2012 Feb;233(2):767-75. doi: 10.1016/j.expneurol.2011.11.036. Epub 2011 Dec 8.

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Biochem Biophys Res Commun. 2011 May 20;408(4):602-8. doi: 10.1016/j.bbrc.2011.04.068. Epub 2011 Apr 22.

Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges.脑小血管病：从发病机制和临床特征到治疗挑战。

Lancet Neurol. 2010 Jul;9(7):689-701. doi: 10.1016/S1474-4422(10)70104-6.

Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial: a double-blind, active and placebo-controlled study.在有效避免二次中风预防方案（PRoFESS）试验中，阿司匹林加缓释双嘧达莫与氯吡格雷及替米沙坦对缺血性中风患者复发性中风后残疾和认知功能的影响：一项双盲、活性药物与安慰剂对照研究。

Lancet Neurol. 2008 Oct;7(10):875-84. doi: 10.1016/S1474-4422(08)70198-4. Epub 2008 Aug 29.

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Cilostazol and Probucol for Cognitive Decline after Stroke: A Cognitive Outcome Substudy of the PICASSO Trial.

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