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Cilostazol and Probucol for Cognitive Decline after Stroke: A Cognitive Outcome Substudy of the PICASSO Trial.

作者信息

Lim Jae-Sung, Kwon Sun U, Yu Kyung-Ho, Yu Sungwook, Park Jong-Ho, Lee Byung-Chul, Oh Mi Sun, Kim Yong-Jae, Rha Joung-Ho, Hwang Yang-Ha, Lee Ji Sung, Heo Sung Hyuk, Ahn Seong Hwan, Seo Woo-Keun, Park Jong-Moo, Lee Ju-Hun, Kwon Jee-Hyun, Sohn Sung-Il, Jung Jin-Man, Kim Hahn Young, Kim Eung-Gyu, Cha Jae-Kwan, Park Man-Seok, Nam Hyo Suk, Bae Hee-Joon, Kim Dong-Eog, Park Jaeseol, Kang Yeonwook, Choi Jimi, Lee Juneyoung

机构信息

Department of Neurology, Hallym University Sacred Heart Hospital, Hallym Neurological Institute, Hallym University College of Medicine, Anyang, Korea.

Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

出版信息

J Stroke. 2021 Jan;23(1):128-131. doi: 10.5853/jos.2020.03650. Epub 2021 Jan 31.

DOI:10.5853/jos.2020.03650
PMID:33600710
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7900397/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01cc/7900397/5ad2743e922d/jos-2020-03650f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01cc/7900397/5ad2743e922d/jos-2020-03650f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01cc/7900397/5ad2743e922d/jos-2020-03650f1.jpg

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Cilostazol and Probucol for Cognitive Decline after Stroke: A Cognitive Outcome Substudy of the PICASSO Trial.西洛他唑和普罗布考治疗卒中后认知功能减退：PICASSO试验的认知结局子研究
J Stroke. 2021 Jan;23(1):128-131. doi: 10.5853/jos.2020.03650. Epub 2021 Jan 31.
2
Design and Rationale for a Cognitive Outcome Substudy in Ischemic Stroke Patients with High Risk of Cerebral Hemorrhage.脑出血高危缺血性脑卒中患者认知结局子研究的设计与原理
J Stroke Cerebrovasc Dis. 2016 Aug;25(8):2061-6. doi: 10.1016/j.jstrokecerebrovasdis.2016.04.028. Epub 2016 Jun 1.
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Changes in High-Density Lipoprotein Cholesterol and Risks of Cardiovascular Events: A Post Hoc Analysis from the PICASSO Trial.高密度脂蛋白胆固醇变化与心血管事件风险：PICASSO试验的事后分析
J Stroke. 2020 Jan;22(1):108-118. doi: 10.5853/jos.2019.02551. Epub 2020 Jan 31.
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Rationale and design of the PreventIon of CArdiovascular events in iSchemic Stroke patients with high risk of cerebral hemOrrhage (PICASSO) study: A randomized controlled trial.脑出血高危缺血性卒中患者心血管事件预防（PICASSO）研究的原理与设计：一项随机对照试验
Int J Stroke. 2015 Oct;10(7):1153-8. doi: 10.1111/ijs.12519. Epub 2015 Jun 4.
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Design and Rationale of the Intima-Medial Thickness Sub-Study of the PreventIon of CArdiovascular Events in iSchemic Stroke Patients with High Risk of Cerebral hemOrrhage (PICASSO-IMT) Study.脑出血高危缺血性卒中患者心血管事件预防（PICASSO-IMT）研究中内膜中层厚度子研究的设计与原理
J Stroke Cerebrovasc Dis. 2017 Sep;26(9):1892-1898. doi: 10.1016/j.jstrokecerebrovasdis.2017.06.035. Epub 2017 Jul 22.
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Cilostazol Versus Aspirin in Ischemic Stroke Patients With High-Risk Cerebral Hemorrhage: Subgroup Analysis of the PICASSO Trial.西洛他唑与阿司匹林治疗伴有高出血风险的缺血性脑卒中患者的疗效比较： PICASSO 试验的亚组分析。
Stroke. 2020 Mar;51(3):931-937. doi: 10.1161/STROKEAHA.119.023855. Epub 2019 Dec 20.
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Combinatorial effect of probucol and cilostazol in focal ischemic mice with hypercholesterolemia.普罗布考和西洛他唑联合应用对高胆固醇血症局灶性脑缺血小鼠的作用。
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Effects of combination therapy with cilostazol and probucol versus monotherapy with cilostazol on coronary plaque, lipid and biomarkers: SECURE study, a double-blind randomized controlled clinical trial.西洛他唑与普罗布考联合治疗对比西洛他唑单药治疗对冠状动脉斑块、血脂及生物标志物的影响：SECURE研究，一项双盲随机对照临床试验
J Atheroscler Thromb. 2014;21(8):816-30. doi: 10.5551/jat.22657. Epub 2014 Apr 4.
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Using MemTrax memory test to screen for post-stroke cognitive impairment after ischemic stroke: a cross-sectional study.使用MemTrax记忆测试筛查缺血性中风后的中风后认知障碍：一项横断面研究。
Front Hum Neurosci. 2023 Jul 17;17:1195220. doi: 10.3389/fnhum.2023.1195220. eCollection 2023.
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Efficacy and safety of cilostazol in decreasing progression of cerebral white matter hyperintensities-A randomized controlled trial.

本文引用的文献

1
Prevention of cardiovascular events in Asian patients with ischaemic stroke at high risk of cerebral haemorrhage (PICASSO): a multicentre, randomised controlled trial.亚洲缺血性脑卒中高危脑出血风险患者的心血管事件预防（PICASSO）：一项多中心、随机对照试验。
Lancet Neurol. 2018 Jun;17(6):509-518. doi: 10.1016/S1474-4422(18)30128-5.
2
STROKOG (stroke and cognition consortium): An international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease.STROKOG（卒中与认知联盟）：一个旨在研究与脑血管疾病相关的神经认知障碍的流行病学、诊断和治疗的国际联盟。
Alzheimers Dement (Amst). 2016 Nov 18;7:11-23. doi: 10.1016/j.dadm.2016.10.006. eCollection 2017.
3
西洛他唑在降低脑白质高信号进展方面的疗效和安全性——一项随机对照试验
Alzheimers Dement (N Y). 2022 Dec 27;8(1):e12369. doi: 10.1002/trc2.12369. eCollection 2022.
4
Association between Blood Pressure, Blood Pressure Variability, and Post-Stroke Cognitive Impairment.血压、血压变异性与卒中后认知障碍之间的关联
Biomedicines. 2021 Jul 2;9(7):773. doi: 10.3390/biomedicines9070773.
Design and Rationale for a Cognitive Outcome Substudy in Ischemic Stroke Patients with High Risk of Cerebral Hemorrhage.
脑出血高危缺血性脑卒中患者认知结局子研究的设计与原理
J Stroke Cerebrovasc Dis. 2016 Aug;25(8):2061-6. doi: 10.1016/j.jstrokecerebrovasdis.2016.04.028. Epub 2016 Jun 1.
4
Effects of long-term blood pressure lowering and dual antiplatelet treatment on cognitive function in patients with recent lacunar stroke: a secondary analysis from the SPS3 randomised trial.近期腔隙性卒中患者长期降压和双联抗血小板治疗对认知功能的影响：来自 SPS3 随机试验的二次分析。
Lancet Neurol. 2014 Dec;13(12):1177-85. doi: 10.1016/S1474-4422(14)70224-8. Epub 2014 Oct 23.
5
Cilostazol add-on therapy in patients with mild dementia receiving donepezil: a retrospective study.在接受多奈哌齐治疗的轻度痴呆患者中使用西洛他唑附加疗法：一项回顾性研究。
PLoS One. 2014 Feb 26;9(2):e89516. doi: 10.1371/journal.pone.0089516. eCollection 2014.
6
Cognitive impairment in lacunar strokes: the SPS3 trial.腔隙性卒中患者的认知功能障碍：SPS3 试验。
Ann Neurol. 2012 Sep;72(3):351-62. doi: 10.1002/ana.23733.
7
Probucol, a lipid-lowering drug, prevents cognitive and hippocampal synaptic impairments induced by amyloid β peptide in mice.普罗布考，一种降脂药物，可预防淀粉样β肽在小鼠体内引起的认知和海马突触损伤。
Exp Neurol. 2012 Feb;233(2):767-75. doi: 10.1016/j.expneurol.2011.11.036. Epub 2011 Dec 8.
8
Protective effect of the phosphodiesterase III inhibitor cilostazol on amyloid β-induced cognitive deficits associated with decreased amyloid β accumulation.磷酸二酯酶 III 抑制剂西洛他唑对淀粉样 β 诱导的认知功能障碍的保护作用与淀粉样 β 积聚减少有关。
Biochem Biophys Res Commun. 2011 May 20;408(4):602-8. doi: 10.1016/j.bbrc.2011.04.068. Epub 2011 Apr 22.
9
Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges.脑小血管病：从发病机制和临床特征到治疗挑战。
Lancet Neurol. 2010 Jul;9(7):689-701. doi: 10.1016/S1474-4422(10)70104-6.
10
Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial: a double-blind, active and placebo-controlled study.在有效避免二次中风预防方案（PRoFESS）试验中，阿司匹林加缓释双嘧达莫与氯吡格雷及替米沙坦对缺血性中风患者复发性中风后残疾和认知功能的影响：一项双盲、活性药物与安慰剂对照研究。
Lancet Neurol. 2008 Oct;7(10):875-84. doi: 10.1016/S1474-4422(08)70198-4. Epub 2008 Aug 29.