School of Public Health,Curtin University, Perth, WA, Australia; Research and Training Department, Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia.
School of Public Health,Curtin University, Perth, WA, Australia.
J Affect Disord. 2021 Apr 1;284:149-156. doi: 10.1016/j.jad.2021.02.024. Epub 2021 Feb 8.
While previous studies have suggested that maternal anxiety and depressive symptoms are associated with increased risk of attention-deficit/hyperactivity disorder (ADHD) in their offspring in early and late childhood, studies exploring the risk in late adolescence are however lacking. This study aims to examine the association between maternal anxiety and depressive symptoms and the risk of ADHD symptoms in late adolescence (at age 17).
We used data from the Raine Study. Maternal depressive and anxiety symptoms were measured when the child was 10 years of age using the Depression, Anxiety, and Stress Scale (DASS). Offspring ADHD symptoms at age 17 were assessed using the DSM-oriented scales of the child behavior checklist (CBCL). Log-binomial regression was used to explore the associations.
We found an increased risk of ADHD symptoms in offspring of mothers with comorbid anxiety and depressive symptoms when compared with offspring of mothers with no symptoms [RR 5.60 (95%CI 3.02-10.37)]. There was a nearly three-fold increase in the risk of ADHD symptoms in offspring of mothers with increased anxiety symptoms compared with offspring of mothers who were in the normal range [RR 2.84 (95%CI 1.18-6.83)]. No association was observed with maternal depressive symptoms.
This study found an increased risk of ADHD symptoms in the offspring of mothers with anxiety as well as comorbid anxiety and depressive symptoms but not among the offspring of mothers with depressive symptoms. Early screening and intervention for ADHD symptoms in offspring with maternal anxiety and comorbid anxiety and depressive symptoms are warranted.
尽管先前的研究表明，母亲的焦虑和抑郁症状与儿童早期和晚期患注意力缺陷多动障碍（ADHD）的风险增加有关，但缺乏探索青少年晚期风险的研究。本研究旨在探讨母亲的焦虑和抑郁症状与青少年晚期（17 岁）ADHD 症状风险之间的关系。
我们使用了 Raine 研究的数据。在孩子 10 岁时，使用抑郁、焦虑和压力量表（DASS）测量了母亲的抑郁和焦虑症状。在孩子 17 岁时，使用儿童行为检查表（CBCL）的 DSM 定向量表评估了子女的 ADHD 症状。使用对数二项式回归来探索关联。
与无症状母亲的子女相比，患有焦虑和抑郁共病的母亲的子女患 ADHD 症状的风险增加[RR5.60（95%CI3.02-10.37）]。与处于正常范围内的母亲的子女相比，焦虑症状增加的母亲的子女患 ADHD 症状的风险增加了近三倍[RR2.84（95%CI1.18-6.83）]。与母亲的抑郁症状无关。
本研究发现，患有焦虑症以及焦虑和抑郁共病的母亲的子女患 ADHD 症状的风险增加，但患有抑郁症的母亲的子女则没有。需要对有焦虑症和焦虑及抑郁共病的母亲的子女进行 ADHD 症状的早期筛查和干预。
