Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.
Departments of Pediatrics, Environmental Medicine, and Population Health, School of Medicine, New York University, New York City, New York.
Fertil Steril. 2020 Feb;113(2):435-443. doi: 10.1016/j.fertnstert.2019.09.034.
To study the associations between maternal polycystic ovary syndrome (PCOS) and hirsutism with offspring attention-deficit/hyperactivity disorder (ADHD), anxiety, conduct disorder, and behavioral problems.
Prospective birth cohort study.
Not applicable.
PATIENT(S): A total of 1,915 mother-child dyads.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Maternal report of offspring ADHD, anxiety, or conduct disorder diagnosis at 7 to 8 years; emotional symptoms, behavioral problems (including peer relationship, conduct, hyperactivity/inattention), and prosocial problems measured with the Strengths and Difficulties Questionnaire (SDQ) at 7 years.
RESULT(S): Prevalence of PCOS and hirsutism were 12.0% and 3.9%; 84% of women with hirsutism had PCOS. After adjustment for sociodemographic covariates, prepregnancy body mass index, and parental history of affective disorders, children born to mothers with PCOS had higher risk of anxiety (adjusted risk ratio [aRR] 1.62; 95% confidence interval [CI], 1.02-2.57) and borderline emotional symptoms (aRR 1.66; 95% CI, 1.18-2.33) compared with children born to mothers without PCOS. The associations between maternal PCOS and offspring ADHD were positive but imprecise. Maternal hirsutism was related to a higher risk of children's ADHD (aRR 2.33; 95% CI, 1.28-4.24), conduct disorder (aRR 2.54; 95% CI 1.18-5.47), borderline emotional symptoms, peer relationship problems, and conduct problems (aRRs 2.61; 95% CI, 1.69-4.05; 1.92; 95% CI, 1.16-3.17; and 2.22; 95% CI, 1.30-3.79, respectively).
CONCLUSION(S): Maternal PCOS was associated with offspring anxiety, and hirsutism was related to other offspring behavioral problems. These findings should be interpreted with caution as replication is needed in prospective cohort studies that assess PCOS and hirsutism diagnoses using medical records.
研究母体多囊卵巢综合征（PCOS）和多毛症与后代注意缺陷/多动障碍（ADHD）、焦虑、品行障碍和行为问题之间的关联。
前瞻性出生队列研究。
不适用。
共有 1915 对母婴对子。
无。
7 至 8 岁时，母亲报告后代 ADHD、焦虑或品行障碍诊断；7 岁时，采用《长处和困难问卷》（SDQ）评估情绪症状、行为问题（包括同伴关系、品行、多动/注意力不集中）和亲社会问题。
PCOS 和多毛症的患病率分别为 12.0%和 3.9%；84%的多毛症患者患有 PCOS。在校正社会人口学协变量、孕前体重指数和父母情感障碍病史后，与未患 PCOS 的母亲所生的孩子相比，患有 PCOS 的母亲所生的孩子更易患焦虑症（调整后的风险比 [aRR] 1.62；95%置信区间 [CI]，1.02-2.57）和边缘情绪症状（aRR 1.66；95%CI，1.18-2.33）。母体 PCOS 与后代 ADHD 之间的关联呈阳性但不精确。母体多毛症与儿童 ADHD（aRR 2.33；95%CI，1.28-4.24）、品行障碍（aRR 2.54；95%CI，1.18-5.47）、边缘情绪症状、同伴关系问题和行为问题的风险增加相关（aRRs 2.61；95%CI，1.69-4.05；1.92；95%CI，1.16-3.17；和 2.22；95%CI，1.30-3.79，分别）。
母体 PCOS 与后代焦虑有关，多毛症与其他后代行为问题有关。这些发现应谨慎解释，因为需要在使用医疗记录评估 PCOS 和多毛症诊断的前瞻性队列研究中进行复制。
