中国人群估算肾小球滤过率的年龄和性别特异性参考值。

Age- and Sex-Specific Reference Values of Estimated Glomerular Filtration Rate in Chinese Population.

机构信息

Department of Nephrology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.

Department of Nephrology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China,

出版信息

Gerontology. 2021;67(4):397-402. doi: 10.1159/000513451. Epub 2021 Feb 18.

DOI:10.1159/000513451

PMID:33601388

Abstract

BACKGROUND

Due to an aging population, prevalence and mortality of CKD continue to increase. Current CKD definition has been challenged recently. Age- and sex-specific reference values of estimated glomerular filtration rate (eGFR) in China are still lacking.

METHODS

Age- and sex-stratified, randomly selected inhabitants received a health examination and an inquest into medical history. The GFR was estimated using CKD-EPI equation. We calculated means with ±1.96 times of standard deviation and 2.5th, 97.5th percentiles of eGFR per 5-year age-group. Some of their GFRs were measured by the Gates method (99mTc-DTPA renal scintigraphy) and estimated by cystatin C-based equation.

RESULTS

The cohort study included 17,037 male and 9,304 female Chinese persons aged 18-99 years. A reference population of apparently healthy subjects was selected by excluding persons with known hypertension, diabetes, cardiovascular, or renal diseases. This healthy cohort study included 12,231 male subjects and 6,463 female subjects. The mean eGFR was higher in the female than that in the male who were younger than 40-year (122 mL/min/1.73 m2 vs. 111 mL/min/1.73 m2). In these apparently healthy persons, GFR declined approximately 0.8 mL/min/year. The lower limit of eGFR (2.5th percentile or mean minus 1.96 times of standard deviation) was <60 or 45 mL/min/1.73 m2 at the age of ≥40 or 65 years old, respectively.

CONCLUSION

The mean eGFR was higher in young females. GFR declined approximately 0.8 mL/min/year. The lower bound of eGFR was <60 mL/min/1.73 m2 or 45 mL/min/1.73 m2 at the age of ≥40 or ≥65 years, respectively. Our study provides age- and sex-specific reference values of GFR in a Chinese population.

摘要

背景

由于人口老龄化，慢性肾脏病（CKD）的患病率和死亡率持续上升。目前的 CKD 定义最近受到了挑战。中国仍然缺乏年龄和性别特异性估算肾小球滤过率（eGFR）参考值。

方法

按年龄和性别分层，随机选择居民接受健康检查和病史调查。使用 CKD-EPI 方程估计 GFR。我们计算了每 5 岁年龄组 eGFR 的均数及其±1.96 倍标准差和 2.5 百分位数、97.5 百分位数。他们的一些 GFR 是用 99mTc-DTPA 肾闪烁法（Gates 法）测量的，并用基于胱抑素 C 的方程估计。

结果

该队列研究包括 17037 名男性和 9304 名女性，年龄 18-99 岁。通过排除已知患有高血压、糖尿病、心血管或肾脏疾病的患者，选择了一个无明显疾病的参考人群。这项健康队列研究包括 12231 名男性和 6463 名女性。在 40 岁以下的人群中，女性的平均 eGFR 高于男性（122mL/min/1.73m2 比 111mL/min/1.73m2）。在这些无明显疾病的人群中，GFR 每年下降约 0.8mL/min。eGFR 的下限（2.5 百分位数或均数减去 1.96 倍标准差）分别在≥40 或≥65 岁时<60 或 45mL/min/1.73m2。