Department of Biomedical Laboratory Science, University for Development Studies, Tamale, Ghana.
Physiol Rep. 2022 Nov;10(22):e15516. doi: 10.14814/phy2.15516.
The 2D:4D ratio is the putative marker of prenatal hormone exposure and has been suggested as a correlate of adult circulating testosterone and estrogen. The study aimed to determine whether sexual dimorphism in the estimated glomerular filtration rate (eGFR) can be partly explained by the 2D:4D ratio or adult circulating testosterone or estrogen. The study was cross-sectional from June to December 2021 at the University for Development Studies. The study involved 206 healthy adults (Female = 93, Male = 113) between 18 and 30 years. The 2D:4D ratio was measured using computer-assisted analysis. Venous blood samples were collected and analyzed for testosterone, estradiol and creatinine using the ELISA technique and routine biochemical analysis. The adjusted eGFR was calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine equation (2021). The eGFR and the testosterone-to-estradiol ratio (TT:E ) were significantly higher in males than in females (p < 0.001). There was a significant interaction between sex and the TT:E on the eGFR (p < 0.001). Although the relationship between the eGFR and the TT:E was negative in both males and females, a unit change in the TT:E had a greater impact on the eGFR in females (B = -1.38) than in males (B = -0.01). Sexual dimorphism in the eGFR is influenced by both testosterone and estradiol. Although the sex difference in the eGFR may be influenced by the TT:E , estrogen seems to account for more variability in the eGFR than testosterone.
2D:4D 比率是产前激素暴露的假定标志物，被认为与成年循环睾酮和雌激素有关。本研究旨在确定肾小球滤过率（eGFR）的性别二态性是否可以部分通过 2D:4D 比率或成年循环睾酮或雌激素来解释。该研究于 2021 年 6 月至 12 月在发展研究大学进行，为横断面研究。研究对象为 18 至 30 岁之间的 206 名健康成年人（女性=93 人，男性=113 人）。使用计算机辅助分析测量 2D:4D 比率。采集静脉血样，使用 ELISA 技术和常规生化分析检测睾酮、雌二醇和肌酐。使用慢性肾脏病流行病学合作组（CKD-EPI）肌酐方程（2021 年）计算调整后的 eGFR。eGFR 和睾酮-雌二醇比值（TT:E）在男性中显著高于女性（p<0.001）。eGFR 与 TT:E 之间的性别交互作用显著（p<0.001）。尽管 eGFR 与 TT:E 之间呈负相关，但 TT:E 的单位变化对女性 eGFR 的影响大于男性（B=-1.38 比 B=-0.01）。eGFR 的性别二态性受睾酮和雌二醇的影响。尽管 eGFR 的性别差异可能受 TT:E 影响，但雌激素似乎比睾酮对 eGFR 的变异性影响更大。
