壳聚糖/明胶共混涂层修饰的ω-3PUFAs 浓缩纳米脂质体的增强物理化学稳定性。
Enhanced physicochemical stability of ω-3 PUFAs concentrates-loaded nanoliposomes decorated by chitosan/gelatin blend coatings.
机构信息
Department of Seafood Processing, Faculty of Marine Sciences, Tarbiat Modares University, P.O. Box 46414-356, Noor, Iran.
Department of Seafood Processing, Faculty of Marine Sciences, Tarbiat Modares University, P.O. Box 46414-356, Noor, Iran.
出版信息
Food Chem. 2021 May 30;345:128865. doi: 10.1016/j.foodchem.2020.128865. Epub 2020 Dec 13.
To enhance the physicochemical stability of ω-3 PUFAs concentrates from fish oil, biopolymer coating based on chitosan (CH) and gelatin (GE) deposited on the surface of nanoliposomes (NLs) has been synthesized and characterized. The mean particle size of surface-decorated nanoliposomes (SDNLs) containing ω-3 PUFAs concentrates was found to be in the range of 209.5-454.3 nm. Scanning and transmission electron microscopy revealed the spherical shape and smooth surface of the nanovesicles. Fourier-transform infrared spectroscopy and X-ray diffraction observations confirmed that the NLs have been successfully coated by biopolymeric blends. The highest entrapment efficiency of 81.6% was obtained in polymer-stabilized NLs with a concentration ratio of 0.3:0.1 (CH:GE). Differential scanning calorimetry results revealed enhanced thermal stability of vesicles after polymeric blend desorption. Finally, the oxidative stability assays demonstrated that the ω-3 PUFAs concentrates entrapped in SDNLs was protected against oxidation in comparison to the free ω-3 PUFAs concentrates.
为了提高鱼油中 ω-3 多不饱和脂肪酸浓缩物的物理化学稳定性，已合成并表征了基于壳聚糖（CH）和明胶（GE）的生物聚合物涂层，该涂层沉积在纳米脂质体（NL）的表面。含有 ω-3 多不饱和脂肪酸浓缩物的表面修饰纳米脂质体（SDNL）的平均粒径在 209.5-454.3nm 范围内。扫描和透射电子显微镜显示纳米囊泡呈球形且表面光滑。傅里叶变换红外光谱和 X 射线衍射观察证实 NL 已成功涂覆了生物聚合物共混物。在聚合物稳定的 NL 中，当浓度比为 0.3:0.1（CH:GE）时，获得了 81.6%的最高包封效率。差示扫描量热法结果表明，聚合物共混物解吸后囊泡的热稳定性得到提高。最后，氧化稳定性试验表明，与游离 ω-3 多不饱和脂肪酸浓缩物相比，包封在 SDNL 中的 ω-3 多不饱和脂肪酸浓缩物具有更好的抗氧化能力。
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