基于下额前回的静息态功能连接与双相障碍轻躁狂/躁狂、轻躁狂相、抑郁相的持续性注意力。
Inferior frontal gyrus seed-based resting-state functional connectivity and sustained attention across manic/hypomanic, euthymic and depressive phases of bipolar disorder.
机构信息
Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, P R China; Mental Health Center, West China Hospital of Sichuan University, Chengdu, China; Brain Research Center, West China Hospital of Sichuan University, Chengdu, China.
Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, P R China; Mental Health Center, West China Hospital of Sichuan University, Chengdu, China; Brain Research Center, West China Hospital of Sichuan University, Chengdu, China.
出版信息
J Affect Disord. 2021 Mar 1;282:930-938. doi: 10.1016/j.jad.2020.12.199. Epub 2021 Jan 6.
OBJECTIVE
Seed-based resting-state functional connectivity (rs-FC) of inferior frontal gyrus (IFG), as well as sustained attention cognitive deficit are consistently reported to be impaired in bipolar disorders. However, whether these deficits exist across mood states and euthymic state are lacking. We compared rs-FC of IFG and sustained attention of bipolar patients in (hypo) mania, depression and euthymia, with controls. We also explored the interrelationships between clinical, cognitive, and imaging measurements.
METHODS
Participants included 110 bipolar subjects: 46 manic/hypomanic, 35 euthymic, and 29 depressed, matched with 41 healthy controls (HCs) underwent structural magnetic resonance imaging (MRI) and resting-state functional MRI scans. Seed-based functional connectivity analyses were performed focused on bilateral IFG seeds. Clinical symptoms and sustained attention function were measured. Stepwise linear regression analysis was conducted to explore predictors of sustained attention measurements.
RESULTS
Increased rs-FC between right IFG and bilateral frontal pole/superior frontal gyrus, precuneus, and posterior cingulate gyrus, as well as decreased rs-FC between right IFG and sensorimotor areas, anterior middle cingulate gyrus were found in all three bipolar subgroups compared with HCs. Impaired sustained attention measurement was found in bipolar manic/hypomanic and depressive subgroups compared with HCs. Linear regression analyses revealed a significant impact of the manic symptoms and psychotic symptoms on the performance of sustained attention task.
CONCLUSIONS
Our results revealed that IFG seed-based resting-state functional networks involved in emotion regulation and cognitive function were trait-like deficit in bipolar patients. Higher manic levels and psychotic symptoms were predictors of a worse sustained attention performance.
目的
下额前回（IFG）的基于种子的静息态功能连接（rs-FC）以及持续注意力认知缺陷在双相情感障碍中一直被报道存在受损。然而，这些缺陷是否存在于情绪状态和轻躁狂状态尚不清楚。我们比较了双相情感障碍患者在（轻）躁狂、抑郁和轻躁狂状态下、与对照组相比，IFG 的 rs-FC 和持续注意力的情况。我们还探讨了临床、认知和影像学测量之间的相互关系。
方法
参与者包括 110 名双相情感障碍患者：46 名躁狂/轻躁狂、35 名轻躁狂、29 名抑郁，与 41 名健康对照（HCs）相匹配，进行了结构磁共振成像（MRI）和静息态功能磁共振成像扫描。基于种子的功能连接分析集中在双侧 IFG 种子上进行。测量临床症状和持续注意力功能。进行逐步线性回归分析，以探索持续注意力测量的预测因素。
结果
与 HCs 相比，所有三个双相情感障碍亚组均发现右侧 IFG 与双侧额极/额上回、顶叶内囊和后扣带回之间的 rs-FC 增加，以及右侧 IFG 与感觉运动区、前中扣带回之间的 rs-FC 减少。与 HCs 相比，双相情感障碍躁狂/轻躁狂和抑郁亚组的持续注意力测量受损。线性回归分析显示，躁狂症状和精神病症状对持续注意力任务的表现有显著影响。
结论
我们的研究结果表明，IFG 种子的静息态功能网络与情绪调节和认知功能有关，是双相情感障碍患者的特质性缺陷。较高的躁狂水平和精神病症状是持续注意力表现较差的预测因素。
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