Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, China; School of Humanities and Social Sciences, Shanxi Medical University, Taiyuan, China.
Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, China.
Brain Res. 2021 Jan 1;1750:147143. doi: 10.1016/j.brainres.2020.147143. Epub 2020 Oct 15.
This study aims to identify how the large-scale brain dynamic functional connectivity (dFC) differs between mood states in bipolar disorder (BD). The authors analyzed dFC in subjects with BD in depressed and euthymic states using resting-state functional magnetic resonance imaging (rsfMRI) data, and compared these states to healthy controls (HCs).
20 subjects with BD in a depressive episode, 23 euthymic BD subjects, and 31 matched HCs underwent rsfMRI scans. Using an existing parcellation of the whole brain, we measured dFC between brain regions and identified the different patterns of brain network connections between groups.
In the analysis of whole brain dFC, the connectivity between the left Superior Temporal Gyrus (STG) in the somatomotor network (SMN), the right Middle Temporal Gyrus (MTG) in the default mode network (DMN) and the bilateral Postcentral Gyrus (PoG) in the DMN of depressed BD was greater than that of euthymic BD, while there was no significant difference between euthymic BD and HCs in these brain regions. Euthymic BD patients had abnormalities in the frontal-striatal-thalamic (FST) circuit compared to HCs.
Differences in dFC within and between DMN and SMN can be used to distinguish depressed and euthymic states in bipolar patients. The hyperconnectivity within and between DMN and SMN may be a state feature of depressed BD. The abnormal connectivity of the FST circuit can help identify euthymic BD from HCs.
本研究旨在确定双相情感障碍（BD）患者在不同心境状态下的大脑大范围动态功能连接（dFC）有何不同。作者使用静息态功能磁共振成像（rsfMRI）数据，分析了处于抑郁发作和轻躁狂状态的 BD 患者的 dFC，并将这些状态与健康对照（HC）进行了比较。
20 名处于抑郁发作的 BD 患者、23 名轻躁狂 BD 患者和 31 名匹配的 HC 接受了 rsfMRI 扫描。使用现有的大脑整体分区方法，我们测量了大脑区域之间的 dFC，并确定了不同组之间的大脑网络连接模式。
在整个大脑 dFC 的分析中，处于抑郁发作的 BD 患者的左侧颞上回（STG）与躯体运动网络（SMN）之间、右侧颞中回（MTG）与默认模式网络（DMN）之间以及双侧后中央回（PoG）与 DMN 之间的连接较轻躁狂 BD 患者增强，而轻躁狂 BD 患者与 HC 之间在这些脑区没有显著差异。轻躁狂 BD 患者的额纹状体丘脑（FST）回路异常，与 HC 相比。
DMN 和 SMN 内和之间的 dFC 差异可用于区分双相患者的抑郁和轻躁狂状态。DMN 和 SMN 内和之间的过度连接可能是抑郁 BD 的一种状态特征。FST 回路的异常连接有助于从 HC 中识别轻躁狂 BD。
