Zhang Leyi, Yan Haohao, Zhang Chunguo, Li Xiaoling, Liang Jiaquan, Tang Chaohua, Wu Weibin, Deng Wen, Xie Guojun, Guo Wenbin
Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Department of Psychiatry, The Third People's Hospital of Foshan, Foshan, Guangdong, China.
CNS Neurosci Ther. 2025 Feb;31(2):e70236. doi: 10.1111/cns.70236.
The resting-state functional connectivity (FC) patterns of the fronto-parietal network (FPN) and language network (LN) underlying bipolar disorder (BD) are obscure. This study aimed to uncover abnormal FC patterns of FPN and LN underlying BD and their evolution following treatment.
Imaging data at rest state and clinical variables were acquired from 82 patients with BD (with 43 finishing the follow-up) and 88 healthy controls (HCs). Seed-based FC analysis was performed, and correlations between FCs and clinical variables were investigated with whole-brain multiple regression analyses. Furthermore, a neuroimaging-transcription spatial association analysis was conducted.
At baseline, BD patients presented elevated FPN-LN and FPN-prefrontal gyrus FCs, and hyperconnectivity between the LN and bilateral thalamus, right angular gyrus (AG), and right cerebellum. Following 3 months of treatment intervention, there were decreased FCs between the FPN and left superior temporal gyrus (STG), left superior frontal gyrus (SFG), left insula, and bilateral middle temporal gyrus (MTG) (part of LN). Neuroimaging transcription analysis discovered genes correlated with FC alterations in BD.
Aberrant FC patterns of FPN and LN might be involved in the neural pathogenetic and therapeutic mechanisms of BD. We also provided potential genetic pathways underlying these functional impairments in BD.
双相情感障碍（BD）患者额顶叶网络（FPN）和语言网络（LN）的静息态功能连接（FC）模式尚不明确。本研究旨在揭示BD患者FPN和LN的异常FC模式及其治疗后的演变情况。
收集了82例BD患者（其中43例完成随访）和88名健康对照（HCs）的静息态影像数据及临床变量。进行基于种子点的FC分析，并通过全脑多元回归分析研究FC与临床变量之间的相关性。此外，还进行了神经影像 - 转录空间关联分析。
基线时，BD患者的FPN - LN和FPN - 前额叶回FC升高，LN与双侧丘脑、右侧角回（AG）和右侧小脑之间存在高连接性。经过3个月的治疗干预后，FPN与左侧颞上回（STG）、左侧额上回（SFG）、左侧岛叶以及双侧颞中回（MTG，LN的一部分）之间的FC降低。神经影像转录分析发现了与BD中FC改变相关的基因。
FPN和LN的异常FC模式可能参与了BD的神经发病机制和治疗机制。我们还提供了BD中这些功能障碍潜在的遗传途径。
