3749St Mark's Hospital, Harrow, London, United Kingdom.
* Nikolaos Kamperidis and Vasileios Kamperidis are sharing first authorship.
Angiology. 2021 Apr;72(4):303-314. doi: 10.1177/0003319720974552. Epub 2020 Dec 2.
Atherosclerosis and inflammatory bowel disease (IBD) are often regarded as 2 distinct entities. The commonest manifestation of atherosclerosis is ischemic heart disease (IHD), and an association between IHD and IBD has been reported. Atherosclerosis and IBD share common pathophysiological mechanisms in terms of their genetics, immunology, and contributing environmental factors. Factors associated with atherosclerosis are implicated in the development of IBD and vice versa. Therefore, treatments targeting the common pathophysiology pathways may be effective in both conditions. The current review considers the pathophysiological pathways that are shared between the 2 conditions and discusses the implications for treatment and research.
动脉粥样硬化和炎症性肠病（IBD）通常被视为两种截然不同的实体。动脉粥样硬化最常见的表现是缺血性心脏病（IHD），并且已经报道了 IHD 和 IBD 之间的关联。在遗传学、免疫学和促成环境因素方面，动脉粥样硬化和 IBD 具有共同的病理生理机制。与动脉粥样硬化相关的因素与 IBD 的发展有关，反之亦然。因此，针对共同病理生理途径的治疗方法可能对这两种疾病都有效。本综述考虑了这两种疾病共有的病理生理途径，并讨论了对治疗和研究的影响。
