Leon H. Charney Division of Cardiology, Department of Medicine, Center for the Prevention of Cardiovascular Disease, New York University School of Medicine, 530 First Avenue, Skirball 9R, New York, NY, 10016, USA.
Department of Medicine, VA New York Harbor Healthcare System, New York, NY, USA.
Sci Rep. 2021 Feb 18;11(1):4053. doi: 10.1038/s41598-021-83466-9.
Thrombosis is a major concern in respiratory infections. Our aim was to investigate the magnitude and duration of risk for arterial and venous thrombosis following discharge after respiratory infection. Patients with respiratory infections were identified using the United States Nationwide Readmission Database from 2012 to 2014. Patients admitted with asthma or cellulitis served as comparators. Readmissions for acute myocardial infarction (MI) and venous thromboembolism (VTE) were evaluated at 30 to 180 days. The likelihood of a first thrombotic event after discharge was compared with a 30-day period prior to hospitalization. Among 5,271,068 patients discharged after a respiratory infection, 0.56% and 0.78% were readmitted within 30-days with MI and VTE, respectively. Relative to asthma and cellulitis, respiratory infection was associated with a greater age and sex-adjusted hazard of 30-day readmission for MI (adjusted HR [aHR] 1.48 [95% CI 1.42-1.54] vs. asthma; aHR 1.36 [95% CI 1.31-1.41] vs. cellulitis) and VTE (aHR 1.28 [95% CI 1.24-1.33] vs. asthma; aHR 1.26, [95% CI 1.22-1.30] vs. cellulitis). Risks of MI and VTE attenuated over time. In a crossover-cohort analysis, the odds of MI (OR 1.68 [95% CI 1.62-1.73]) and VTE (OR 3.30 [95% 3.19-3.41]) were higher in the 30 days following discharge after respiratory infection than during the 30-day baseline period. Hospitalization for respiratory infection was associated with increased risks of thrombosis that were highest in the first 30-days after discharge and declined over time.
血栓形成是呼吸道感染的主要关注点。我们的目的是研究呼吸道感染出院后动脉和静脉血栓形成的风险程度和持续时间。使用美国全国再入院数据库，从 2012 年到 2014 年，确定患有呼吸道感染的患者。患有哮喘或蜂窝织炎的患者作为对照组。在 30 至 180 天内评估急性心肌梗死（MI）和静脉血栓栓塞（VTE）的再入院情况。与住院前 30 天相比，比较出院后首次血栓事件的可能性。在 5271068 例因呼吸道感染出院的患者中，分别有 0.56%和 0.78%在 30 天内因 MI 和 VTE 再入院。与哮喘和蜂窝织炎相比，呼吸道感染与 30 天内 MI（校正后危险比 [aHR] 1.48 [95% CI 1.42-1.54] vs. 哮喘；aHR 1.36 [95% CI 1.31-1.41] vs. 蜂窝织炎）和 VTE（aHR 1.28 [95% CI 1.24-1.33] vs. 哮喘；aHR 1.26，[95% CI 1.22-1.30] vs. 蜂窝织炎）再入院的风险增加有关。MI 和 VTE 的风险随时间减弱。在交叉队列分析中，MI（OR 1.68 [95% CI 1.62-1.73]）和 VTE（OR 3.30 [95% 3.19-3.41]）的可能性在呼吸道感染出院后的 30 天内高于 30 天的基线期。呼吸道感染住院与血栓形成风险增加有关，出院后前 30 天风险最高，随时间降低。
