Gordon M, Preiksaitis H G
Baycrest Hospital, Toronto, Canada.
Geriatrics. 1988 May;43(5):69-71, 75-88.
The aging brain is more sensitive to the potentially deleterious effects of drugs used to treat common geriatric disorders. The atypical presentation of medical conditions can lead to inaccurate diagnoses and inappropriate drug prescribing. Working from a knowledge of general principles of geriatric pharmacokinetics and pharmacodynamics, the clinician will be better attuned to the problems of prescribing for the elderly, so as to maximize beneficial therapeutic effects without compromising mental function.
衰老的大脑对用于治疗常见老年疾病的药物潜在有害影响更为敏感。疾病的非典型表现可能导致诊断不准确和药物处方不当。基于老年药代动力学和药效学的一般原则知识,临床医生将能更好地适应为老年人开处方的问题,从而在不损害精神功能的情况下最大化有益的治疗效果。