Kato Kumiko, Takeuchi Maki, Yonekawa Yuka, Kashima Yuzen, Hirano Koji, Kondo Mineo
Department of Ophthalmology, Mie University Graduate School of Medicine, Tsu, Japan.
Department of Ophthalmology, Fujita Health University Bantane Hospital, Nagoya, Japan.
Clin Ophthalmol. 2021 Feb 12;15:559-564. doi: 10.2147/OPTH.S299288. eCollection 2021.
To report our findings in three cases of an inflamed conjunctival nevus whose size and degree of pigmentation were reduced by topical antiallergic and immunosuppressive ophthalmic solutions.
Observational case series. Three patients with inflamed conjunctival nevus were examined by slit-lamp biomicroscopy, and the findings before and after the treatments were compared.
All three patients had a slightly pigmented and edematous conjunctival tumor at the corneal limbal area. The tumors were hyperemic, and papillae and follicles were present on the superior conjunctiva in all patients. All of the patients had an allergic predisposition. The antiallergic treatment not only resolved the hyperemia and edema of the palpebral conjunctiva, but also reduced the tumor size. In one case, the topical antiallergic agent alone led to a reduction of the tumor size. A combination of topical antiallergic agent and topical immunosuppressant was effective in reducing the tumor size and degree of pigmentation in the other two patients.
The hyperemia and pigmentation in eyes with inflamed conjunctival nevus can be resolved by topical antiallergic agent and topical immunosuppressant without resection of the tumor.
报告3例炎症性结膜痣患者的研究结果,这些患者使用局部抗过敏和免疫抑制眼药水后,痣的大小和色素沉着程度均有所减轻。
观察性病例系列。对3例炎症性结膜痣患者进行裂隙灯生物显微镜检查,并比较治疗前后的结果。
所有3例患者角膜缘区均有轻度色素沉着且水肿的结膜肿物。肿物充血,所有患者上睑结膜均有乳头和滤泡。所有患者均有过敏倾向。抗过敏治疗不仅消除了睑结膜的充血和水肿,还缩小了肿物大小。在1例患者中,单独使用局部抗过敏药物导致肿物大小减小。局部抗过敏药物与局部免疫抑制剂联合使用对另外2例患者减小肿物大小和色素沉着程度有效。
局部抗过敏药物和局部免疫抑制剂可消除炎症性结膜痣患者的充血和色素沉着,而无需切除肿物。