Wang Weiwei, Gao Ju
Department of Anesthesiology, Clinical Medical College of Yangzhou University, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China.
Exp Ther Med. 2021 Mar;21(3):228. doi: 10.3892/etm.2021.9659. Epub 2021 Jan 20.
Melatonin (MT; N-acetyl-5-methoxy-tryptamine), which has multiple effects and roles, is secreted from the pineal gland at night according to the daily rhythm. In addition to circadian regulation, MT has anti-inflammatory, antioxidant and anticancer functions. Recent studies postulated that MT serves a critical role in apoptosis, anti-ischemic reperfusion injury and anti-proliferative effects on various cells. The current review reported on the underlying mechanism behind the protective effect of MT on lung diseases, such as acute lung injury, acute respiratory distress syndrome, chronic obstructive pulmonary disease, lung ischemia-reperfusion injury, sepsis-induced lung injury and ventilator-induced lung injury. MT is considered an adjuvant with therapeutic drugs for preventing inflammation and is responsible for regulating patient sleep cycles in the intensive care unit. The current review described the anti-inflammatory and antioxidant efficiency of MT with a focus on the molecular mechanisms of action in various lung injuries.
褪黑素（MT；N-乙酰-5-甲氧基色胺）具有多种作用和功能，根据昼夜节律，它在夜间由松果体分泌。除昼夜调节外，MT还具有抗炎、抗氧化和抗癌功能。最近的研究推测，MT在细胞凋亡、抗缺血再灌注损伤以及对各种细胞的抗增殖作用中起关键作用。本综述报道了MT对肺部疾病（如急性肺损伤、急性呼吸窘迫综合征、慢性阻塞性肺疾病、肺缺血再灌注损伤、脓毒症诱导的肺损伤和呼吸机诱导的肺损伤）保护作用的潜在机制。MT被认为是预防炎症的治疗药物佐剂，负责在重症监护病房调节患者的睡眠周期。本综述描述了MT的抗炎和抗氧化功效，重点关注其在各种肺损伤中的分子作用机制。
