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Evaluation of immunological responses against outer membrane vesicles (OMV) of nontypeable using MPLA-CpG adjuvant as a vaccine candidate.

作者信息

Behrouzi Ava, Mianroodi Reza Arabi, Afrough Parviz, Ayadi Ahmad, Serajian Amirarsalan

机构信息

Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran.

Department of R&D, Research and Production Complex, Pasteur Institute of Iran, Tehran, Iran.

出版信息

Iran J Microbiol. 2020 Oct;12(5):417-423. doi: 10.18502/ijm.v12i5.4602.

DOI:10.18502/ijm.v12i5.4602
PMID:33603996
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7867700/
Abstract

BACKGROUND AND OBJECTIVES: Nontypeable (NTHi) are major causes of non-invasive infections, including otitis media and sinusitis and it can also contribute to respiratory infections of all ages. Currently, there is no licensed vaccine against NTHi commercially available. Many studies have been conducted on the use of OMV as a vaccine against NTHi. The purpose of this study is to achieve an immunogenic vaccine against NTHi. MATERIALS AND METHODS: In this study, standard OMV (ATCC49766) with adjuncts CpG and MPLA was used and after infusion into BALB/c mice, the levels of antibodies and cytokines were measured on serum of immunized mice. RESULTS: The results showed that total IgG antibody and IgG1 and IgG2a isotypes in OMV immunized mice with mixture of CpG-MPLA adjuvant had a significant increase. Also, the results of cytokines (IL-10, IL-4 and IFN-γ) showed that IL-4 had the highest rate. CONCLUSION: These findings indicate that OMVs derived from NTHi strains have a high potential to act as a vaccine against NTHi infections.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b362/7867700/918c17b44afb/IJM-12-417-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b362/7867700/4a1543c4e424/IJM-12-417-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b362/7867700/8bdbb80e755b/IJM-12-417-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b362/7867700/c061f425c2a5/IJM-12-417-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b362/7867700/0c0a65dae1b5/IJM-12-417-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b362/7867700/918c17b44afb/IJM-12-417-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b362/7867700/4a1543c4e424/IJM-12-417-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b362/7867700/8bdbb80e755b/IJM-12-417-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b362/7867700/c061f425c2a5/IJM-12-417-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b362/7867700/0c0a65dae1b5/IJM-12-417-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b362/7867700/918c17b44afb/IJM-12-417-g005.jpg

相似文献

[1]
Evaluation of immunological responses against outer membrane vesicles (OMV) of nontypeable using MPLA-CpG adjuvant as a vaccine candidate.

Iran J Microbiol. 2020-10

[2]
Immunogenicity of Nontypeable Haemophilus influenzae Outer Membrane Vesicles and Protective Ability in the Chinchilla Model of Otitis Media.

Clin Vaccine Immunol. 2017-10-5

[3]
Intranasal immunization with nontypeable Haemophilus influenzae outer membrane vesicles induces cross-protective immunity in mice.

PLoS One. 2012-8-3

[4]
Immunization with Protein D from Non-Typeable (NTHi) Induced Cytokine Responses and Bioactive Antibody Production.

Jundishapur J Microbiol. 2016-9-11

[5]
Nasal vaccination with CpG oligodeoxynucleotide induces protective immunity against non-typeable Haemophilus influenzae in the nasopharynx.

Laryngoscope. 2006-3

[6]
Intranasal immunization enhances clearance of nontypeable Haemophilus influenzae and reduces stimulation of tumor necrosis factor alpha production in the murine model of otitis media.

Infect Immun. 2001-5

[7]
A basis for vaccine development: Comparative characterization of Haemophilus influenzae outer membrane vesicles.

Int J Med Microbiol. 2015-5

[8]
A bacterial vaccine polypeptide protective against nontypable Haemophilus influenzae.

Vaccine. 2020-3-23

[9]
A recombinant P4 protein of Haemophilus influenzae induces specific immune responses biologically active against nasopharyngeal colonization in mice after intranasal immunization.

Vaccine. 2005-1-26

[10]
Recombinant truncated E protein as a new vaccine candidate against nontypeable H. influenzae: Its expression and immunogenic evaluation.

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引用本文的文献

[1]
The Role of Bacterial Extracellular Vesicles in the Immune Response to Pathogens, and Therapeutic Opportunities.

Int J Mol Sci. 2024-6-5

[2]
Otitis media: recent advances in otitis media vaccine development and model systems.

Front Microbiol. 2024-1-24

[3]
A Robust Protocol to Isolate Outer Membrane Vesicles from Nontypeable .

Methods Protoc. 2023-4-7

本文引用的文献

[1]
Update on non-typeable Haemophilus influenzae-mediated disease and vaccine development.

Expert Rev Vaccines. 2018-6-18

[2]
Nontypeable Haemophilus influenzae DNA stimulates type I interferon expression via STING signaling pathway.

Biochim Biophys Acta Mol Cell Res. 2018-2-5

[3]
Evaluation of immunological responses to recombinant Porin A protein (rPoA) from native strains of Neisseria meningitidis serogroups A and B using OMV as an adjuvant in BALB/c mice.

Microb Pathog. 2017-9-20

[4]
Evaluation of the immunogenic property of NT H. influenzae protein D with Neisseria meningitidis OMV in BALB/c.

J Infect Dev Ctries. 2016-12-30

[5]
Phase I, randomized, observer-blind, placebo-controlled studies to evaluate the safety, reactogenicity and immunogenicity of an investigational non-typeable Haemophilus influenzae (NTHi) protein vaccine in adults.

Vaccine. 2016-6-8

[6]
Developing a vaccine to prevent otitis media caused by nontypeable Haemophilus influenzae.

Expert Rev Vaccines. 2016-7

[7]
A basis for vaccine development: Comparative characterization of Haemophilus influenzae outer membrane vesicles.

Int J Med Microbiol. 2015-5

[8]
Diversion of the host humoral response: a novel virulence mechanism of Haemophilus influenzae mediated via outer membrane vesicles.

J Leukoc Biol. 2014-2-18

[9]
Absence of an important vaccine and diagnostic target in carriage- and disease-related nontypeable Haemophilus influenzae.

Clin Vaccine Immunol. 2014-2

[10]
Relative contributions of lipooligosaccharide inner and outer core modifications to nontypeable Haemophilus influenzae pathogenesis.

Infect Immun. 2013-8-26

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