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一名青少年的慢性免疫性血小板减少症和桥本甲状腺炎:病例介绍及意义

Chronic Immune Thrombocytopenia and Hashimoto's Hypothyroidism in an Adolescent: Presentation and Implications.

作者信息

Ibrahim Judy, Alashqar Mohammad, Al Zaabi Shamma, Trad Omar, Al Shibli Amar

机构信息

Academic Affairs Department, Tawam Hospital, Al Ain, UAE.

Hematology-Oncology Department, Tawam Hospital, Al Ain, UAE.

出版信息

Case Rep Pediatr. 2021 Feb 1;2021:6649155. doi: 10.1155/2021/6649155. eCollection 2021.

Abstract

Immune thrombocytopenia (ITP) is a disorder characterized by immune-mediated destruction of thrombocytes leading to peripheral blood platelet count of <100 × 10^9/L. Primary ITP is a terminology used in the absence of other causes or disorders that may be associated with thrombocytopenia, i.e., isolated thrombocytopenia. The term secondary ITP is used if such diseases coexist. We present here a case of a 14-year-old female diagnosed with immune thrombocytopenia. When her evaluation was not strongly supportive of primary ITP, she was screened and proved to have a concomitant Hashimoto thyroiditis. Contrary to the popular belief about secondary ITP in adult population, treatment of our patient's hypothyroidism did not improve her platelet's count, and the patient needed multiple immunosuppressive medications to improve her condition.

摘要

免疫性血小板减少症(ITP)是一种以免疫介导的血小板破坏为特征的疾病,导致外周血血小板计数<100×10^9/L。原发性ITP是在不存在其他可能与血小板减少症相关的病因或疾病(即孤立性血小板减少症)时使用的术语。如果此类疾病并存,则使用继发性ITP这一术语。我们在此报告一例14岁女性被诊断为免疫性血小板减少症的病例。当对她的评估并不强烈支持原发性ITP时,她接受了筛查并被证明同时患有桥本甲状腺炎。与成人继发性ITP的普遍看法相反,治疗我们患者的甲状腺功能减退症并未改善她的血小板计数,患者需要多种免疫抑制药物来改善病情。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c6/7872745/497af980eece/CRIPE2021-6649155.001.jpg

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