Yang Lihong, Xiao Dongqiong, Li Xihong, Lai Chunqi, Chen Yuhao, Pan Lingli
Department of Emergency, West China Second University Hospital, Sichuan University, Chengdu, China.
Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), Sichuan University, Chengdu, China.
Front Pediatr. 2023 Jun 9;11:1169064. doi: 10.3389/fped.2023.1169064. eCollection 2023.
Immune thrombocytopenia (ITP) is one of the most prevalent acquired bleeding disorders in children, which is primarily characterized by a decrease in platelet count. It can be classified into two subtypes: primary ITP and secondary ITP. The underlying mechanisms causing ITP are complex and not fully comprehended. Helicobacter pylori (H. pylori) infections can lead to ITP and potentially trigger various autoimmune diseases. Furthermore, there is evidence of a correlation between thyroid disease and ITP. In this case report, we describe the case of an 11-year-old patient who presented with ITP, Hashimoto's thyroiditis (HT), and H. pylori infection. Following anti-H. pylori treatment and thyroxine supplementation, the child's platelet count increased compared to the previous count. The limitation of this report is that the platelet count of this child returned to normal after anti-H. pylori and thyroxine supplementation, so we cannot distinguish the effect of anti-H. pylori and thyroxine supplementation on the platelet count in this child. Despite this limitation, we still believe that early screening for thyroid function and H. pylori, as well as prompt eradication of H. pylori, along with thyroxine supplementation, may be beneficial in treating and improving the prognosis of children diagnosed with ITP.
免疫性血小板减少症（ITP）是儿童中最常见的获得性出血性疾病之一，其主要特征是血小板计数减少。它可分为两个亚型：原发性ITP和继发性ITP。导致ITP的潜在机制复杂且尚未完全明了。幽门螺杆菌（H. pylori）感染可导致ITP，并可能引发各种自身免疫性疾病。此外，有证据表明甲状腺疾病与ITP之间存在关联。在本病例报告中，我们描述了一名11岁患者的病例，该患者患有ITP、桥本甲状腺炎（HT）和H. pylori感染。经过抗H. pylori治疗和补充甲状腺素后，该患儿的血小板计数较之前有所增加。本报告的局限性在于，该患儿在抗H. pylori和补充甲状腺素后血小板计数恢复正常，因此我们无法区分抗H. pylori和补充甲状腺素对该患儿血小板计数的影响。尽管存在这一局限性，我们仍然认为早期筛查甲状腺功能和H. pylori，以及及时根除H. pylori并补充甲状腺素，可能有助于治疗并改善被诊断为ITP的儿童的预后。
