Khan Chachar Aijaz Zeeshan, Khan Khurshid, Khan Asma A, Muhammad Imran Hasan Khan, Ashraf Zia Muhammad, Siddique Nasir, Bin Younis Bilal, Khan Zohaib Ahmad
Medicine, Fatima Memorial Hospital College of Medicine and Dentistry, Lahore, PAK.
Medicine and Endocrinology, Fatima Memorial Hospital College of Medicine and Dentistry, Lahore, PAK.
Cureus. 2021 Jan 12;13(1):e12663. doi: 10.7759/cureus.12663.
Background The first case of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was diagnosed in Wuhan, China, in 2019. By the first half of 2020, coronavirus disease 2019 (COVID-19) turned into a global pandemic. Objectives The aim of this study is to describe the clinical and demographic characteristics including comorbidities and their outcomes among patients hospitalized with COVID-19 in four tertiary care hospitals across Lahore This retrospective study was conducted at Fatima Memorial Hospital, Sir Ganga Ram Hospital, Lahore General Hospital, and Jinnah Hospital, all in Lahore, Pakistan, from May 1, 2020, to June 30, 2020. The sample size was 445, which was derived using the convenient sampling method. Clinical outcomes during hospitalization included the requirement of invasive positive pressure ventilation, need for renal replacement therapy (RRT), and death. Data regarding demographics, baseline comorbidities, important vital signs on reporting, and initial workup with results were also collected. Results A total of 445 patients' data were studied, of whom 291 (65.4%) were male patients and 154 (34.6%) female patients. The median age was 54 years (interquartile range [IQR]: 24). The most common comorbidities were hypertension (HTN) (195; 43.8%) followed by diabetes mellitus (DM) (168; 37.8%) and cardiovascular disease (CVD) (61; 13.7%). The median length of hospital stay was eight days (IQR: 3). Of the total patients, 137 (30.7%) were treated in intensive care unit settings, 40 (9%) received invasive mechanical ventilation, 40 (9%) patients had acute kidney injury, 38 (8.5%) received RRT, and 37 (8.3%) died. It was seen that more patients who were either diabetic or hypertensive received invasive mechanical ventilation as compared to those who did not have these comorbidities. The most common radiological finding on chest X-ray was the classical ground-glass appearance of COVID-19, which was found in 318 (71.4%) patients. Conclusions Patients with one or more underlying comorbidities had poor clinical outcomes compared to those with no comorbidities, with the most vulnerable group being patients with chronic kidney disease, DM, HTN, and CVD in descending order.
背景 2019年，中国武汉确诊了首例严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染病例。到2020年上半年，2019冠状病毒病（COVID-19）演变成一场全球大流行。目的 本研究旨在描述拉合尔市四家三级医疗医院中COVID-19住院患者的临床和人口统计学特征，包括合并症及其结局。这项回顾性研究于2020年5月1日至2020年6月30日在巴基斯坦拉合尔的法蒂玛纪念医院、冈加拉姆爵士医院、拉合尔综合医院和真纳医院进行。样本量为445，采用方便抽样法获得。住院期间的临床结局包括有创正压通气需求、肾脏替代治疗（RRT）需求和死亡。还收集了有关人口统计学、基线合并症、报告时的重要生命体征以及初始检查结果的数据。结果 共研究了445例患者的数据，其中男性患者291例（65.4%），女性患者154例（34.6%）。年龄中位数为54岁（四分位间距[IQR]：24）。最常见的合并症是高血压（HTN）（195例；43.8%），其次是糖尿病（DM）（16
