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金刚烷胺预防由 SARS-CoV-2 引起的临床症状。

Amantadine in the prevention of clinical symptoms caused by SARS-CoV-2.

机构信息

Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.

Universidad Veracruzana/Instituto de Investigaciones Cerebrales, Xalapa, Veracruz, Mexico.

出版信息

Pharmacol Rep. 2021 Jun;73(3):962-965. doi: 10.1007/s43440-021-00231-5. Epub 2021 Feb 18.

DOI:10.1007/s43440-021-00231-5
PMID:33604795
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7891470/
Abstract

BACKGROUND

Amantadine is a drug that can help in the prevention of SARS-CoV-2 symptomatology, as has been demonstrated in observational clinical studies.

METHODS

We searched in the PubMed database Clinical Studies of coronavirus-infected patients who have been treated with amantadine in a preventive manner as well as patients with Parkinson's disease.

RESULTS

Four clinical studies were found in which relatives of patients with COVID-19 had been prescribed the use of amantadine in a preventive manner to avoid the symptoms caused by the coronavirus.

CONCLUSION

Amantadine is a drug that can be prescribed as a prophylactic that prevents symptomatology caused by SARS-CoV-2 coronavirus.

摘要

背景

金刚烷胺是一种可以帮助预防 SARS-CoV-2 症状的药物，这已经在观察性临床研究中得到证实。

方法

我们在 PubMed 数据库中搜索了接受金刚烷胺预防性治疗的冠状病毒感染患者以及帕金森病患者的临床研究。

结果

我们发现了四项临床研究，其中 COVID-19 患者的亲属被开处金刚烷胺用于预防，以避免冠状病毒引起的症状。

结论

金刚烷胺是一种可以作为预防药物来预防 SARS-CoV-2 冠状病毒引起的症状。

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Amantadine in the prevention of clinical symptoms caused by SARS-CoV-2.金刚烷胺预防由 SARS-CoV-2 引起的临床症状。
Pharmacol Rep. 2021 Jun;73(3):962-965. doi: 10.1007/s43440-021-00231-5. Epub 2021 Feb 18.
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本文引用的文献

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Docking Prediction of Amantadine in the Receptor Binding Domain of Spike Protein of SARS-CoV-2.金刚烷胺在新型冠状病毒刺突蛋白受体结合域中的对接预测
ACS Pharmacol Transl Sci. 2020 Nov 3;3(6):1430-1433. doi: 10.1021/acsptsci.0c00172. eCollection 2020 Dec 11.
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Antiviral activity and safety of remdesivir against SARS-CoV-2 infection in human pluripotent stem cell-derived cardiomyocytes.瑞德西韦在人多能干细胞衍生的心肌细胞中抗 SARS-CoV-2 感染的抗病毒活性和安全性。
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Observational study of people infected with SARS-Cov-2, treated with amantadine.对感染 SARS-CoV-2 并接受金刚烷胺治疗的人群进行的观察性研究。
Pharmacol Rep. 2020 Dec;72(6):1538-1541. doi: 10.1007/s43440-020-00168-1. Epub 2020 Oct 10.
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Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19.羟氯喹治疗 COVID-19 住院患者的疗效。
N Engl J Med. 2020 Nov 19;383(21):2030-2040. doi: 10.1056/NEJMoa2022926. Epub 2020 Oct 8.
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Pharmacological profile of natural and synthetic compounds with rigid adamantane-based scaffolds as potential agents for the treatment of neurodegenerative diseases.具有刚性金刚烷骨架的天然和合成化合物的药理学特性，作为治疗神经退行性疾病的潜在药物。
Biochem Biophys Res Commun. 2020 Sep 3;529(4):1225-1241. doi: 10.1016/j.bbrc.2020.06.123. Epub 2020 Aug 7.
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Arch Med Res. 2020 Oct;51(7):714. doi: 10.1016/j.arcmed.2020.07.001. Epub 2020 Jul 3.
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