Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM'S NMIMS, V.L Mehta Road, Vile Parle(W), Mumbai, India.
School of Pharmacy, Faculty of Health and Medical Sciences, Taylor's University, 47500, Subang Jaya, Selangor, Malaysia.
Drug Deliv Transl Res. 2022 Jan;12(1):105-123. doi: 10.1007/s13346-021-00935-4. Epub 2021 Feb 18.
The biocompatible nature of mesoporous silica nanoparticles (MSN) attracted researchers' attention to deliver therapeutic agents in the treatment of various diseases, where their porous nature, high drug loading efficiency, and suitability to functionalize with a specific ligand of MSN helped to obtain the desired outcome. The application of MSN has been extended to deliver small chemicals to large-sized peptides or proteins to fight against complex diseases. Recently, formulation researches with MSN have been progressed for various non-conventional drug delivery systems, including liposome, microsphere, oro-dispersible film, 3D-printed formulation, and microneedle. Low bulk density, retaining mesoporous structure during downstream processing, and lack of sufficient in vivo studies are some of the important issues towards the success of mesoporous silica-based advanced drug delivery systems. The present review has aimed to evaluate the application of MSN in advanced drug delivery systems to critically analyze the role of MSN in the respective formulation over other functionalized polymers. Finally, an outlook on the future direction of MSN-based advanced drug delivery systems has been drawn against the existing challenges with this platform.
介孔硅纳米粒子（MSN）具有良好的生物相容性，这引起了研究人员的关注，使其可用于递送治疗剂来治疗各种疾病。MSN 的多孔性、高载药效率以及适合与 MSN 的特定配体功能化的特性，有助于实现预期的效果。MSN 的应用已经扩展到递送小分子到大型肽或蛋白质，以对抗复杂疾病。最近，MSN 在各种非传统药物递送系统中的制剂研究取得了进展，包括脂质体、微球、口腔分散膜、3D 打印制剂和微针。低堆密度、在下游处理过程中保留介孔结构以及缺乏充分的体内研究是介孔硅基先进药物递送系统成功的一些重要问题。本综述旨在评估 MSN 在先进药物递送系统中的应用，以批判性地分析 MSN 在各自制剂中的作用，以及其与其他功能化聚合物相比的作用。最后，针对该平台存在的挑战，对基于 MSN 的先进药物递送系统的未来发展方向进行了展望。
