Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenhe District, Shenyang, Liaoning Province, PR China.
Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenhe District, Shenyang, Liaoning Province, PR China.
Nanomedicine. 2015 Feb;11(2):313-27. doi: 10.1016/j.nano.2014.09.014. Epub 2014 Nov 13.
UNLABELLED: In the past decade, mesoporous silica nanoparticles (MSNs) with a large surface area and pore volume have attracted considerable attention for their application in drug delivery and biomedicine. In this review, we highlight the recent advances in silica-assisted drug delivery systems, including (1) MSN-based immediate/sustained drug delivery systems and (2) MSN-based controlled/targeted drug delivery systems. In addition, we summarize the biomedical applications of MSNs, including (1) MSN-based biotherapeutic agent delivery; (2) MSN-assisted bioimaging applications; and (3) MSNs as bioactive materials for tissue regeneration. FROM THE CLINICAL EDITOR: This comprehensive review presents recent advances in mesoporous silica nanoparticles assisted drug delivery systems, including both immediate and sustained delivery systems as well as controlled release and targeted drug delivery systems. In addition to achieving therapeutic agent delivery, imaging applications and potential use of silica NPs in tissue regeneration are also discussed.
未加标签：在过去的十年中，具有大表面积和孔体积的介孔硅纳米粒子（MSNs）因其在药物输送和生物医学中的应用而受到极大关注。在这篇综述中，我们强调了最近在硅烷辅助药物输送系统方面的进展，包括（1）基于 MSN 的即时/持续药物输送系统和（2）基于 MSN 的控制/靶向药物输送系统。此外，我们总结了 MSNs 的生物医学应用，包括（1）基于 MSN 的生物治疗剂输送；（2）MSN 辅助的生物成像应用；以及（3）MSNs 作为组织再生的生物活性材料。
临床编辑：这篇全面的综述介绍了介孔硅纳米粒子辅助药物输送系统的最新进展，包括即时和持续输送系统以及控制释放和靶向药物输送系统。除了实现治疗剂输送外，还讨论了成像应用以及硅纳米粒子在组织再生中的潜在用途。
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