Slowing Igor I, Vivero-Escoto Juan L, Wu Chia-Wen, Lin Victor S-Y
Department of Chemistry and U.S. Department of Energy Ames Laboratory, 0755 Gilman Hall, Iowa State University, Ames, Iowa 50011-3111, USA.
Adv Drug Deliv Rev. 2008 Aug 17;60(11):1278-1288. doi: 10.1016/j.addr.2008.03.012. Epub 2008 Apr 10.
In this review, we highlight the recent research developments of a series of surface-functionalized mesoporous silica nanoparticle (MSN) materials as efficient drug delivery carriers. The synthesis of this type of MSN materials is described along with the current methods for controlling the structural properties and chemical functionalization for biotechnological and biomedical applications. We summarized the advantages of using MSN for several drug delivery applications. The recent investigations of the biocompatibility of MSN in vitro are discussed. We also describe the exciting progress on using MSN to penetrate various cell membranes in animal and plant cells. The novel concept of gatekeeping is introduced and applied to the design of a variety of stimuli-responsive nanodevices. We envision that these MSN-based systems have a great potential for a variety of drug delivery applications, such as the site-specific delivery and intracellular controlled release of drugs, genes, and other therapeutic agents.
在本综述中，我们重点介绍了一系列表面功能化介孔二氧化硅纳米颗粒（MSN）材料作为高效药物递送载体的最新研究进展。描述了这类MSN材料的合成方法，以及目前用于控制其结构性质和化学功能化以用于生物技术和生物医学应用的方法。我们总结了将MSN用于多种药物递送应用的优势。讨论了近期关于MSN体外生物相容性的研究。我们还描述了利用MSN穿透动物和植物细胞各种细胞膜方面取得的令人振奋的进展。引入了“守门”这一新颖概念，并将其应用于各种刺激响应纳米器件的设计中。我们设想，这些基于MSN的系统在多种药物递送应用中具有巨大潜力，例如药物、基因和其他治疗剂的位点特异性递送和细胞内控释。
