由B(C₆F₅)₃催化的叔胺与二氢硅烷的连续β,β'-选择性C(sp³)-H硅基化反应
Consecutive β,β'-Selective C(sp )-H Silylation of Tertiary Amines with Dihydrosilanes Catalyzed by B(C F ).
作者信息
Fang Huaquan, Xie Kaixue, Kemper Sebastian, Oestreich Martin
机构信息
Institut für Chemie, Technische Universität Berlin, Strasse des 17. Juni 115, 10623, Berlin, Germany.
出版信息
Angew Chem Int Ed Engl. 2021 Apr 6;60(15):8542-8546. doi: 10.1002/anie.202016664. Epub 2021 Mar 3.
Tris(pentafluorophenyl)borane has been found to catalyze the two-fold C(sp )-H silylation of various trialkylamine derivatives with dihydrosilanes, furnishing the corresponding 4-silapiperidines in decent yields. The multi-step reaction cascade involves amine-to-enamine dehydrogenation at two alkyl residues and two electrophilic silylation reactions of those enamines, one inter- and one intramolecular.
已发现三（五氟苯基）硼烷可催化各种三烷基胺衍生物与二氢硅烷的双C(sp³)-H硅基化反应，以相当不错的产率得到相应的4-硅代哌啶。该多步反应级联涉及两个烷基残基处的胺到烯胺脱氢反应以及这些烯胺的两个亲电硅基化反应，一个分子间反应和一个分子内反应。
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