Sadigursky M, Andrade S G
Braz J Med Biol Res. 1986;19(3):379-88.
An electrocardiographic study was performed on 26 AKR and 32 A/J inbred mice and on 100 Swiss outbred mice, chronically infected with different strains of T. cruzi, characterized as Types I, II and III. The incidence of electrocardiographic alterations in AKR mice was of 87.0%, 80.0% and 83.3% respectively for infection with the Type I, Type II and Type III strains of T. cruzi. In A/J mice the incidence of electrocardiographic alterations was 100% in the infection with the Type I and Type III strains and 26.1% with the Type II strain of T. cruzi. In Swiss mice the electrocardiographic alterations occurred in 53.5% of the mice infected with the Type II strain and in 71.4% of those infected with the Type III strain of T. cruzi. The most frequent electrocardiographic alterations in chronically infected mice, independently of mouse or T. cruzi strain, were first degree AV block, intraventricular conduction abnormalities, sinus tachycardia and bradycardia. The predominant alterations caused by each of the T. cruzi strains varied according to mouse strain. In A/J mice, the electrocardiographic alterations were more frequent in those animals infected with Type I and III strains of T. cruzi and in Swiss mice the alterations were more frequent in those infected with the Type III strain. The results presented in this study demonstrate that the murine model is suitable for electrocardiographic studies related to the heart lesions that occur in Chagas' disease.
对26只AKR和32只A/J近交系小鼠以及100只瑞士远交系小鼠进行了心电图研究，这些小鼠长期感染不同株系的克氏锥虫，分为I型、II型和III型。感染I型、II型和III型克氏锥虫的AKR小鼠心电图改变的发生率分别为87.0%、80.0%和83.3%。在A/J小鼠中，感染I型和III型克氏锥虫株时心电图改变的发生率为100%，感染II型克氏锥虫株时为26.1%。在瑞士小鼠中，感染II型克氏锥虫株的小鼠中有53.5%出现心电图改变，感染III型克氏锥虫株的小鼠中有71.4%出现心电图改变。在慢性感染的小鼠中，无论小鼠或克氏锥虫株系如何，最常见的心电图改变是一度房室传导阻滞、心室内传导异常、窦性心动过速和心动过缓。每种克氏锥虫株系引起的主要改变因小鼠株系而异。在A/J小鼠中，感染I型和III型克氏锥虫株的动物心电图改变更为频繁，而在瑞士小鼠中，感染III型克氏锥虫株的动物心电图改变更为频繁。本研究结果表明，小鼠模型适用于与恰加斯病中心脏病变相关的心电图研究。
