Suppr超能文献

直接抗病毒药物时代的丙型肝炎相关膜增殖性肾小球肾炎。

Hepatitis C-related membranoproliferative glomerulonephritis in the era of direct antiviral agents.

机构信息

Zagazig University, Faculty of Medicine, Internal Medicine Department, Zagazig, Egypt.

Zagazig University, Faculty of Medicine, Pathology Department, Zagazig, Egypt.

出版信息

J Bras Nefrol. 2022 Apr-Jun;44(2):291-295. doi: 10.1590/2175-8239-JBN-2020-0148.

Abstract

Membranoproliferative glomerulonephritis (MPGN) is the most typical Hepatitis C virus (HCV)-associated glomerulopathy, and the available data about the utilization of direct-acting antivirals (DAA) in HCV-associated glomerulonephritis is inadequate. We evaluated the renal and viral response in two cases of HCV-related MPGN; the first caused by cryoglobulinemia while the second was cryoglobulin-negative. Both patients received immunosuppression besides DAA in different regimens. They achieved partial remission but remained immunosuppression-dependent for more than 6 months after DAA despite sustained virological response, which enabled safer but incomplete immunosuppression withdrawal. Both patients were tested for occult HCV in peripheral blood mononuclear cells and found to be negative. Hence, the treatment of HCV-related MPGN ought to be according to the clinical condition and the effects of drug therapy. It is important to consider that renal response can lag behind the virological response.

摘要

膜增生性肾小球肾炎 (MPGN) 是最典型的丙型肝炎病毒 (HCV) 相关性肾小球病,关于直接作用抗病毒药物 (DAA) 在 HCV 相关性肾小球肾炎中的应用的数据不足。我们评估了两例 HCV 相关性 MPGN 的肾脏和病毒反应;第一例由冷球蛋白血症引起,第二例为冷球蛋白阴性。两名患者均接受了 DAA 以外的不同方案的免疫抑制治疗。尽管他们都实现了部分缓解,但在获得持续病毒学应答后仍依赖免疫抑制治疗超过 6 个月,这使得免疫抑制治疗得以更安全地但不完全地停药。两名患者均检测了外周血单个核细胞中的隐匿性 HCV,结果均为阴性。因此,HCV 相关性 MPGN 的治疗应根据临床情况和药物治疗效果而定。重要的是要考虑到肾脏反应可能滞后于病毒学反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc9e/9269171/d0ac61c35848/2175-8239-jbn-2020-0148-gf01.jpg

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验