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与新型β2-支气管扩张剂(NAB 365,盐酸克伦特罗)相比,氢溴酸非诺特罗的支气管扩张作用(作者译)

[The bronchodilatory effect of fenoterol-HBr in comparison to the new beta2-bronchodilator (NAB 365, clenbuterol-HCl) (author's transl)].

作者信息

Dorow P

出版信息

Arzneimittelforschung. 1977;27(10):2020-2.

PMID:336056
Abstract

The effect of 4-amino-alpha-[(tert.-butylamino)methyl]-3,5-dichlorobenzyl alcohol hydrochloride (clenbuterol-HCl NAB 365, Spiropent) in comparison to fenoterol HBr was tested in a doubleblind trial in 30 patients with asthma bronchiale. 3 times daily for 7 days 15 patients inhaled 24 microgram NAB 365 or 5 mg fenoterol HBr respectively. The bronchospasmolytical effect proved optimal as one day after inhalation both test groups showed a significant decrease of resistance in the respiratory system. A quantitative difference of efficacy between the tested bronchodilators did not materialize.

摘要

在一项针对30名支气管哮喘患者的双盲试验中,对4-氨基-α-[(叔丁基氨基)甲基]-3,5-二氯苄醇盐酸盐(盐酸克伦特罗NAB 365,瘦肉精)与氢溴酸非诺特罗的效果进行了测试。15名患者分别每天3次,连续7天吸入24微克NAB 365或5毫克氢溴酸非诺特罗。吸入一天后,两个试验组的呼吸系统阻力均显著降低,支气管解痉效果最佳。所测试的支气管扩张剂之间未出现疗效上的定量差异。

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