Sigg C, Meyer J C, Bruckner-Tuderman L, Gilardi S
Dermatologische Klinik, Universitätsspital Zürich.
Hautarzt. 1988 Feb;39(2):97-101.
In the past there have been several reports of testicular abnormalities (hypogonadism, cryptorchidism and so-called atypical germ cells) in patients with recessive X-linked ichthyosis. Anamnestic interviews, clinical as well as chemical investigations in ten patients (aged 25-52 years) with recessive X-linked ichthyosis have been undertaken in order to examine their endocrine and exocrine testicular function. Normal serum levels of gonadotropins were observed in nine of ten patients, while four of ten men had decreased levels of dehydroepiandrosterone. In addition, in eight of these ten patients spermatological alterations were found: two patients suffered from oligozoospermia, while asthenozzospermia occurred in seven patients and teratozoospermia was registered in three men. Although andrological abnormalities were found in five out of ten patients (cryptorchidism, varicocele), the high incidence of spermatological alterations is remarkable. Further investigations will be necessary to clarify whether steroid sulphatase is responsible for some of these alterations, especially for the pronounced asthenozoospermia.
过去曾有几篇关于隐性X连锁鱼鳞病患者睾丸异常（性腺功能减退、隐睾症和所谓的非典型生殖细胞）的报道。为了检查10名（年龄在25至52岁之间）隐性X连锁鱼鳞病患者的内分泌和外分泌睾丸功能，我们进行了既往史访谈、临床及化学检查。10名患者中有9名促性腺激素血清水平正常，而10名男性中有4名脱氢表雄酮水平降低。此外，在这10名患者中有8名发现了精液学改变：2名患者患有少精子症，7名患者患有弱精子症，3名男性存在畸形精子症。虽然10名患者中有5名存在男科异常（隐睾症、精索静脉曲张），但精液学改变的高发生率值得关注。有必要进一步研究以明确类固醇硫酸酯酶是否与其中一些改变有关，特别是与明显的弱精子症有关。
