Orthopaedic and Rheumatologic Institute, Cleveland Clinic, Cleveland, 44195, Ohio, UK.
Arch Orthop Trauma Surg. 2022 Sep;142(9):2121-2129. doi: 10.1007/s00402-021-03819-x. Epub 2021 Feb 19.
The purpose of this study was to test for differences between patient-reported outcome measures (PROMs) at 1 and 2 years following total hip (THA) or knee (TKA) arthroplasty.
Between 2015 and 2016, n = 469 and n = 414 patients underwent THA and TKA, respectively. Demographic and PROMs data were collected at 1 and 2 years post-operatively. PROMs included Veterans Rand 12-item (VR-12), Hip Injury and Osteoarthritis Outcomes Score (HOOS) Pain subscore, HOOS-Physical Function Short-form (HOOS-PS), Knee Injury and Osteoarthritis Outcomes Score (KOOS) Pain subscore, and KOOS-Physical Function Short-form (KOOS-PS). Paired t tests assessed differences between groups. N = 298 (65.8%) and n = 240 (64%) patients followed-up at 1 year, and 205 (72% of 1-year responders) and 174 (76%) at 2 years in the THA and TKA cohorts, respectively.
No statistically significant differences were observed between 1 and 2 years for HOOS pain (p = 0.445), HOOS-PS (p = 0.265), VR-12 PCS (p = 0.239), VR-12 MCS scores (p = 0.342) in THA and TKA cohorts [KOOS pain (p = 0.242), KOOS-PS (p = 0.088), VR-12 PCS (p < 0.2757), VR-12 MCS scores (p < 0.075)]. There were statistically significant baseline differences between responders and non-responders (patients lost to follow-up), but differences were small and not clinically relevant. PROMs were not significantly different between 1- and 2-year time points for THA and TKA. Minimal demographic or baseline differences between responders and non-responders suggest a representative sample.
These data support a minimum follow-up of 1 year for studies with PROMs as the primary outcome variable following THA and TKA.
本研究旨在测试全髋关节（THA）或全膝关节（TKA）置换术后 1 年和 2 年患者报告的结果测量（PROMs）之间的差异。
在 2015 年至 2016 年期间，分别有 469 名和 414 名患者接受了 THA 和 TKA 手术。术后 1 年和 2 年收集人口统计学和 PROMs 数据。PROMs 包括退伍军人 Rand 12 项（VR-12）、髋关节损伤和骨关节炎结局评分（HOOS）疼痛子评分、HOOS-物理功能简表（HOOS-PS）、膝关节损伤和骨关节炎结局评分（KOOS）疼痛子评分和 KOOS-物理功能简表（KOOS-PS）。配对 t 检验评估了组间差异。在 THA 和 TKA 队列中，分别有 298 名（65.8%）和 240 名（64%）患者在 1 年时进行了随访，205 名（1 年应答者的 72%）和 174 名（76%）患者在 2 年时进行了随访。
THA 和 TKA 队列中，HOOS 疼痛（p=0.445）、HOOS-PS（p=0.265）、VR-12 PCS（p=0.239）、VR-12 MCS 评分（p=0.342）在 1 年和 2 年时均无统计学差异。KOOS 疼痛（p=0.242）、KOOS-PS（p=0.088）、VR-12 PCS（p<0.2757）、VR-12 MCS 评分（p<0.075）在 1 年和 2 年时也无统计学差异。在 THA 和 TKA 中，应答者和未应答者（失访患者）之间存在统计学上的基线差异，但差异较小，且无临床意义。THA 和 TKA 中，1 年和 2 年时间点的 PROMs 无显著差异。应答者和未应答者之间的最小人口统计学或基线差异表明了代表性样本。
这些数据支持在全髋关节和全膝关节置换术后，以 PROMs 为主要结局变量的研究至少随访 1 年。
