多区域序列分析预测肿瘤内异质性和克隆进化。
Multiregion Sequence Analysis to Predict Intratumor Heterogeneity and Clonal Evolution.
机构信息
Division of Statistics, Medical Research Collaborating Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Department of Statistics, University of California, Berkeley, CA, USA.
出版信息
Methods Mol Biol. 2021;2243:283-296. doi: 10.1007/978-1-0716-1103-6_14.
PMID:33606263
Abstract
Multiregion sequencing can advance our understanding of the intratumor heterogeneity and the clonal evolution. Here, we introduced multiple aspects of multiregion sequencing and its analysis, including the study design and sampling strategy, current understanding of the tumor evolution model, and a protocol for multiregion sequencing analysis of DNA-sequencing data.
摘要
多区域测序可以增进我们对肿瘤内异质性和克隆进化的理解。在这里，我们介绍了多区域测序及其分析的多个方面，包括研究设计和采样策略、目前对肿瘤进化模型的理解，以及用于 DNA 测序数据分析的多区域测序分析方案。
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