猪耳毛囊形态参数分析。
Analysis of the morphometric parameters of pig ear hair follicles.
机构信息
Department of Dermatology Venereology and Allergology, Center of Experimental and Applied Cutaneous Physiology, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Charité Universitätsmedizin Berlin, Berlin, Germany.
出版信息
Skin Res Technol. 2021 Sep;27(5):730-738. doi: 10.1111/srt.13008. Epub 2021 Feb 19.
BACKGROUND
Porcine ear skin is used in studies of percutaneous penetration as a substitute for human skin. The objective of the present study was to determine the structure of the hair follicles on the dorsal area of porcine ear skin and make a morphometric comparison with the hair follicles of human skin.
MATERIALS AND METHODS
Sections of frozen biopsies were cut vertically to the skin surface in longitudinal sections using a cryotome and were investigated using microscopy. For each hair follicle, various parameters were determined.
RESULTS
The follicular density in porcine ear skin varies according to the area studied, and the length of most of the follicles was approximately 1458 ± 286 μm. The size of the follicular orifice was also determined in a total of 305 follicles. It showed a diameter of roughly 113 ± 43 μm.
CONCLUSION
The results showed a very good similarity between human and pig hair follicles. Therefore, porcine ear skin can be considered as a very suitable model of human skin in dermal and especially follicular penetration studies.
背景
猪耳皮肤被用于经皮渗透研究，作为人类皮肤的替代物。本研究的目的是确定猪耳皮肤背侧区域毛囊的结构，并与人类皮肤的毛囊进行形态计量学比较。
材料和方法
使用冷冻切片机制备垂直于皮肤表面的冷冻活检切片，并使用显微镜进行研究。为每个毛囊确定了各种参数。
结果
猪耳皮肤的毛囊密度根据研究区域的不同而变化，大多数毛囊的长度约为 1458 ± 286 μm。总共对 305 个毛囊的毛囊口大小进行了测定，其直径约为 113 ± 43 μm。
结论
结果表明，人类和猪的毛囊非常相似。因此，猪耳皮肤可以被认为是一种非常适合用于皮肤和特别是毛囊渗透研究的人类皮肤模型。
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