Plastic and Reconstructive Surgery Division, "Dr. Manuel Gea Gonzalez" General Hospital. National Autonomous University of Mexico.
Stomatology and Orthodontics Division, Hospital General "Dr Manuel Gea Gonzalez," Postgraduate Division of the School of Odontology, National Autonomous University of Mexico, Mexico City, Mexico.
J Craniofac Surg. 2021 Oct 1;32(7):2446-2448. doi: 10.1097/SCS.0000000000007559.
Patients with Moebius syndrome may present a wide range of associated orofacial malformations, however, their craniofacial morphology has not been established via controlled cephalometric studies.
To present our institution's findings in the cephalometric evaluation in patients with Moebius syndrome.
Retrospective, cross-sectional study that included patients with Moebius syndrome over 9 years of age who had lateral cephalometric radiographs. Cephalometric analysis measurements of Ricketts, Steiner, and McNamara were performed. Quantitative data are expressed as mean and standard deviation, and qualitative data are expressed in totals and percentages. Comparative statistics between classic and incomplete Moebius and between patients older and younger than 16 years of age were performed.
Twenty-four patients were included (54.2% females), mean age 17.46 ± 8.85 years. Fifteen patients (62.5%) had classic Moebius syndrome, and nine (37.5%) had incomplete Moebius. Sixty-six percent of the patients presented either micrognathia or retrognathia, 95% showed mandibular hypoplasia, and 75% had a skeletal class II. Maxillary height was increased resulting in a vertical growth pattern. Upper and lower incisors tended towards proclination, and upper and lower lips protruded over cephalometric markings, and a long upper lip was evidenced in 41% of the patients. No significant differences were noted when comparing classic and incomplete Moebius syndrome. Patients younger than 16 years of age had significantly larger sella-nasion-A point and sella-nasion-B point angles, and a higher proportion of skeletal class II cases.
Patients with Moebius syndrome have a vertical maxillary growth, micro or retrognathia, developing a skeletal class II and lip protrusion.
Moebius 综合征患者可能表现出广泛的口面畸形，但他们的颅面形态尚未通过对照性头颅侧位片测量研究确定。
介绍我们机构对 Moebius 综合征患者进行头颅侧位片测量的研究结果。
这是一项回顾性、横断面研究，纳入了年龄超过 9 岁的 Moebius 综合征患者，所有患者均有头颅侧位片。对 Ricketts、Steiner 和 McNamara 头影测量指标进行了分析。定量数据以平均值和标准差表示，定性数据以总数和百分比表示。对经典型和不完全型 Moebius 综合征患者以及年龄大于或小于 16 岁的患者进行了比较统计学分析。
共纳入 24 例患者（54.2%为女性），平均年龄为 17.46±8.85 岁。15 例（62.5%）患者为经典型 Moebius 综合征，9 例（37.5%）为不完全型 Moebius 综合征。66%的患者存在小下颌或下颌后缩，95%的患者存在下颌骨发育不良，75%的患者存在骨性Ⅱ类错合。上颌高度增加，导致垂直生长型。上、下切牙有不同程度的唇倾，上、下唇突度超过头影测量标志，41%的患者上唇较长。经典型和不完全型 Moebius 综合征患者之间无显著差异。年龄小于 16 岁的患者蝶鞍中心点-前鼻棘点-上齿槽座点角和蝶鞍中心点-后鼻棘点-上齿槽座点角明显较大，骨性Ⅱ类错合的比例也更高。
Moebius 综合征患者存在上颌垂直生长、小下颌或下颌后缩，导致骨性Ⅱ类错合和唇突。
