Elde Stefan, Brubaker Aleah L, Than Peter A, Rinewalt Daniel, MacArthur John W, Alassar Aiman, Bonham Clark A, Esquivel Carlos O, Shudo Yasuhiro, Concepcion Waldo, Woo Y Joseph
Department of Cardiothoracic Surgery, Stanford University, Stanford, CA.
Division of Abdominal Transplantation, Department of Surgery, Stanford University, Stanford, CA.
Transplantation. 2021 Dec 1;105(12):2661-2665. doi: 10.1097/TP.0000000000003697.
Combined heart-liver transplant is an emerging option for patients with indications for heart transplantation and otherwise prohibitive hepatic dysfunction. Heart-liver transplantation is particularly relevant for patients with single ventricle physiology who often develop Fontan-associated liver disease and fibrosis. Although only performed at a limited number of centers, several approaches to combined heart-liver transplantation have been described. The en bloc technique offers several potential advantages over the traditional sequential technique. Specifically, en bloc heart-liver transplantation may allow improved hemodynamics, decreased bleeding, reduced liver allograft ischemic time, and may result in reduced rates of graft dysfunction. Here we describe our center's en bloc heart-liver procurement technique in detail, with the aim of allowing broader use and standardization of this technique.
心脏-肝脏联合移植是一种针对有心脏移植指征但存在严重肝功能障碍的患者的新兴选择。心脏-肝脏联合移植对于单心室生理状态的患者尤为重要,这类患者常并发与Fontan手术相关的肝脏疾病和纤维化。尽管心脏-肝脏联合移植仅在少数中心开展,但已有多种方法被描述。与传统的序贯技术相比,整块移植技术具有若干潜在优势。具体而言,整块心脏-肝脏移植可能改善血流动力学、减少出血、缩短肝脏移植物缺血时间,并可能降低移植物功能障碍的发生率。在此,我们详细描述我们中心的整块心脏-肝脏获取技术,旨在使该技术得到更广泛的应用并实现标准化。