USR CNRS-Pierre Fabre No. 3388 ETaC, Centre de Recherche et Développement Pierre Fabre, 31035 Toulouse, France.
Aix Marseille Université, CNRS, Centrale Marseille, Spectropole FR1739, 13397 Marseille, France.
J Nat Prod. 2021 Apr 23;84(4):1198-1202. doi: 10.1021/acs.jnatprod.0c01261. Epub 2021 Feb 19.
Five new quinolizidine alkaloids were isolated from the leaves of (Urb.) Urb. (Caricaceae) and named cylicomorphins A-E (-). They all are ester derivatives of the same basic quinolizidine skeleton bearing hydroxy, methyl, and ethanoic acid substituents. Their structures were mainly established by NMR spectroscopy, and the absolute configuration is proposed on the basis of VCD data and Mosher ester derivatization. Compound displayed cytotoxicity in the 10 μM range against an HCT-116 cell line.
从（Urb.）Urb.（Caricaceae）的叶子中分离得到五个新的喹诺利啶生物碱，命名为环型吗啡 A-E (-)。它们都是具有羟基、甲基和乙酸取代基的相同基本喹诺利啶骨架的酯衍生物。它们的结构主要通过 NMR 光谱确定，根据 VCD 数据和 Mosher 酯衍生化提出了绝对构型。化合物在 10 μM 范围内对 HCT-116 细胞系表现出细胞毒性。
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