来自……的单体、二聚体和三聚体托烷生物碱 。 （你提供的原文不完整，这里只是根据目前内容翻译）
Monomeric, Dimeric, and Trimeric Tropane Alkaloids from .
作者信息
Chan Zi-Yang, Krishnan Premanand, Modaresi Sayed Mohammadhossein, Hii Ling-Wei, Mai Chun-Wai, Lim Wei-Meng, Leong Chee-Onn, Low Yun-Yee, Wong Soon-Kit, Yong Kien-Thai, Leong Alyssa Zi-Xin, Lee Mei-Kee, Ting Kang-Nee, Lim Kuan-Hon
机构信息
School of Pharmacy, University of Nottingham Malaysia, Jalan Broga, 43500 Semenyih, Selangor, Malaysia.
State Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical Stem Cell Research Center, Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
出版信息
J Nat Prod. 2021 Aug 27;84(8):2272-2281. doi: 10.1021/acs.jnatprod.1c00374. Epub 2021 Aug 3.
Seven new tropane alkaloids, including five monomeric (-), one dimeric (), and one trimeric () 3α-nortropane ester, along with two known monomeric nortropane alkaloids ( and ), were isolated from the leaves and bark of . Their structures, including the absolute configuration of the enantiomeric pair of (±)-, were elucidated by comprehensive spectroscopic analyses. Alkaloids and showed cytotoxicity toward human pancreatic cancer cell lines (AsPC-1, BxPC3, PANC-1, and SW1990). Alkaloids , , and induced a smooth muscle relaxation effect comparable to that of atropine ( 106.1 ± 7.5%, 97.0 ± 5.2%, 100.9 ± 1.4%, 111.7 ± 1.7%, respectively) on isolated rat tracheal rings.
从[植物名称]的叶子和树皮中分离出七种新的托烷生物碱，包括五种单体（-）、一种二聚体（）和一种三聚体（）3α-去甲托烷酯，以及两种已知的单体去甲托烷生物碱（和）。通过全面的光谱分析阐明了它们的结构，包括（±）-对映体对的绝对构型。生物碱和对人胰腺癌细胞系（AsPC-1、BxPC3、PANC-1和SW1990）显示出细胞毒性。生物碱、和对离体大鼠气管环产生的平滑肌松弛作用与阿托品相当（分别为106.1±7.5%、97.0±5.2%、100.9±1.4%、111.7±1.7%）。
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