通过 PIEZO1 消除噬血细胞现象。
"Iron"ing out hemophagocytosis through PIEZO1.
机构信息
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Division of Human Genetics, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
出版信息
Cell. 2021 Feb 18;184(4):856-858. doi: 10.1016/j.cell.2021.01.038.
Abstract
In this issue of Cell, Ma et al. reveal a mechanistic role for PIEZO1 in iron homeostasis through molecular genetic mouse studies. They also demonstrate implications for human iron overload and deficiency syndromes, susceptibility to malarial infection, and red blood cell turnover in persons of African ancestries.
摘要
在本期《细胞》杂志中，马等人通过分子遗传小鼠研究揭示了 PIEZO1 在铁稳态中的机制作用。他们还证明了 PIEZO1 与人类铁过载和铁缺乏综合征、对疟疾感染的易感性以及非洲裔人群的红细胞更新有关。
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