Zhang Yihan, Zou Wen, Dou Wenlei, Luo Hongliang, Ouyang Xi
Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, Jiangxi Medical College, Nanchang University, Nanchang, China.
The Second Clinical Medicine School, Jiangxi Medical College, Nanchang University, Nanchang, China.
Front Physiol. 2024 Apr 16;15:1377329. doi: 10.3389/fphys.2024.1377329. eCollection 2024.
Mechanosensitive ion channel protein 1 (Piezo1) is a large homotrimeric membrane protein. Piezo1 has various effects and plays an important and irreplaceable role in the maintenance of human life activities and homeostasis of the internal environment. In addition, recent studies have shown that Piezo1 plays a vital role in tumorigenesis, progression, malignancy and clinical prognosis. Piezo1 is involved in regulating the malignant behaviors of a variety of tumors, including cellular metabolic reprogramming, unlimited proliferation, inhibition of apoptosis, maintenance of stemness, angiogenesis, invasion and metastasis. Moreover, Piezo1 regulates tumor progression by affecting the recruitment, activation, and differentiation of multiple immune cells. Therefore, Piezo1 has excellent potential as an anti-tumor target. The article reviews the diverse physiological functions of Piezo1 in the human body and its major cellular pathways during disease development, and describes in detail the specific mechanisms by which Piezo1 affects the malignant behavior of tumors and its recent progress as a new target for tumor therapy, providing new perspectives for exploring more potential effects on physiological functions and its application in tumor therapy.
机械敏感离子通道蛋白1（Piezo1）是一种大型同三聚体膜蛋白。Piezo1具有多种作用，在维持人类生命活动和内环境稳态方面发挥着重要且不可替代的作用。此外，最近的研究表明，Piezo1在肿瘤发生、发展、恶性程度和临床预后中起着至关重要的作用。Piezo1参与调节多种肿瘤的恶性行为，包括细胞代谢重编程、无限增殖、抑制细胞凋亡、维持干性、血管生成、侵袭和转移。此外，Piezo1通过影响多种免疫细胞的募集、激活和分化来调节肿瘤进展。因此，Piezo1作为抗肿瘤靶点具有巨大潜力。本文综述了Piezo1在人体中的多种生理功能及其在疾病发展过程中的主要细胞途径，并详细描述了Piezo1影响肿瘤恶性行为的具体机制及其作为肿瘤治疗新靶点的最新进展，为探索其对生理功能的更多潜在影响及其在肿瘤治疗中的应用提供了新的视角。
