Effectiveness of eight-week zinc supplementation on vitamin D status and leptin levels in a population of postmenopausal women: a double-blind randomized trial.

BACKGROUND

The menopausal period is characterized by hormonal imbalance related to the alteration of parameters involved in lipid metabolism. In addition, menopause increases the risk of deficiencies of key vitamins and minerals such as vitamin D and zinc in such women. The present study investigates the influence of zinc supplementation on the status of vitamin D and other lipid parameters in postmenopausal women.

METHODS

Fifty-one healthy postmenopausal women aged 44-76 years from the province of Granada (Spain) were divided into two groups (placebo and zinc) of 25 and 26 women, respectively. The zinc group was supplemented with 50 mg/day of zinc for 8 weeks. Nutrient intake assessment was performed by means of a 24 -h reminder. Zinc was determined by flame atomic absorption spectrophotometry. Vitamin D was analyzed by liquid chromatography - tandem mass spectrometry. Leptin was determined by enzyme immunoassay.

RESULTS

Zinc supplementation improved the initial vitamin D status of the postmenopausal population (p = 0.049). Plasma levels of 25-OH-D increased significantly after Zn supplementation in women with lower age at menopause (p = 0.045). Both intake and plasma zinc levels were inversely correlated to serum leptin levels (p = 0.044 and p = 0.033, respectively), being significantly lower in lower age at menopause (p < 0.001).

CONCLUSION

Zinc supplementation improved vitamin D status and was associated to low leptin levels in the postmenopausal women of the study.