Department of Traditional Chinese Medicine, Shanghai Eighth People's Hospital.
Department of Colorectal Surgery, Fudan University Shanghai Cancer Center.
Medicine (Baltimore). 2021 Feb 19;100(7):e24322. doi: 10.1097/MD.0000000000024322.
To investigate whether the Quxie capsule can decrease relapse, metastasis, and symptoms, as well as alleviate the side effects in colorectal cancer (CRC) patients.
A comprehensive literature search of multiple databases was performed. Two reviewers independently selected trials that assessed the relapse-metastasis rate, degree of symptoms, and side effects of Quxie capsule for CRC. The meta-analysis was performed using Review Manager 5.3.
This meta-analysis included 6 studies, with a total of 408 cases. The quality of the included studies was generally low, with only 1 trial of high quality. A statistically significant difference was observed in the relapse-metastasis rate between the Quxie capsule and control groups after 2-years follow-up (n = 185, relative risk (RR) = 0.13, 95% confidence interval (CI) 0.04-0.46; P = .002). The Quxie capsule was found to reduce the traditional Chinese medicine symptom score as compared to the control (n = 208, weighted mean differences (WMD) = -4.15, 95% CI -7.30 to -1.00; P = .010), while it showed no significant improvement in the Karnofsky Performance Status score (n = 138, WMD = 5.05; 95% CI -2.95 to 13.04; P = .22). There was no difference in adverse events between the 2 groups (P = .66).
This systematic review and meta-analysis showed no clear superiority of Quxie capsule for CRC patients receiving chemotherapy. The effect of Quxie capsule in CRC patients should be examined by high quality, large sample size, multi-center RCTs, with longer follow-up.
探讨芪蝎胶囊能否降低结直肠癌（CRC）患者的复发转移率、症状程度及不良反应。
全面检索多个数据库，由 2 位评价者独立筛选评估芪蝎胶囊对 CRC 患者复发转移率、症状程度及不良反应的临床试验。采用 Review Manager 5.3 软件进行 Meta 分析。
本 Meta 分析共纳入 6 项研究，共计 408 例患者。纳入研究的质量总体较低，仅 1 项研究质量较高。2 年随访时，与对照组相比，芪蝎胶囊组的复发转移率差异有统计学意义（n = 185，相对危险度（RR）= 0.13，95%置信区间（CI）0.04-0.46；P = .002）。与对照组相比，芪蝎胶囊可降低中医症状评分（n = 208，加权均数差（WMD）= -4.15，95%CI -7.30 至 -1.00；P = .010），但对卡氏功能状态评分（n = 138，WMD = 5.05；95%CI -2.95 至 13.04；P = .22）的改善作用不明显。两组不良反应发生率差异无统计学意义（P = .66）。
本系统评价和 Meta 分析结果表明，芪蝎胶囊对接受化疗的 CRC 患者无明显优势。应开展高质量、大样本量、多中心 RCT 来进一步检验芪蝎胶囊在 CRC 患者中的疗效，且随访时间应更长。
