Luo Lin, Yang Yu-fei, Li Pei-hong
Department of Oncology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006 Aug;26(8):677-80.
To study the effect of Fuzheng Capsule (FC) and Quxie Capsule (QC) in reducing relapse and metastasis of colorectal cancer in stage II and III after the cancer had been treated by radical operation and succedent routine radiotherapy and chemotherapy.
A prospective cohort controlled study was conducted in 101 patients with colorectal cancer in stage II and III after radical operation and routine radiotherapy and chemotherapy, among whom 53 patients were treated with FC and QC and 48 were given no treatment, they were followed up regularly. The rate and time of relapse and metastasis were observed after 1, 2 and 3 years.
One-year, 2-year and 3-year relapse-metastasis rate was 0, 2.7% and 14.8% respectively in the treated group, and 6.2% , 24.2% and 30.8% in the control group. Significant difference was found only in the 2-year rate between the two groups (chi-squared = 5.428, P < 0.05). Average time of relapse and metastasis was 26.2 +/- 4.5 months in the treated group and 14.2 +/- 4.2 months in the control group, showing significant difference between the two groups (P < 0.05).
FC and QC applying in the succedent consolidating treatment for stage II and III colorectal cancer after radical operation might be favourable to reduce relapse and metastasis and improve quality of life, further clinical study with randomized and controlled method is worthwhile to be conducted.
研究扶正胶囊（FC）和祛邪胶囊（QC）对Ⅱ、Ⅲ期结肠癌根治术后并进行常规放疗及化疗后降低复发和转移的作用。
对101例Ⅱ、Ⅲ期结肠癌根治术后并进行常规放疗及化疗的患者进行前瞻性队列对照研究，其中53例患者接受FC和QC治疗，48例未接受治疗，对他们进行定期随访。观察1、2、3年后的复发和转移率及时间。
治疗组1年、2年和3年的复发转移率分别为0、2.7%和14.8%，对照组分别为6.2%、24.2%和30.8%。两组间仅2年复发转移率差异有统计学意义（χ² = 5.428，P < 0.05）。治疗组复发转移的平均时间为（26.2 ± 4.5）个月，对照组为（14.2 ± 4.2）个月，两组差异有统计学意义（P < 0.05）。
FC和QC应用于Ⅱ、Ⅲ期结肠癌根治术后的后续巩固治疗可能有利于降低复发和转移并提高生活质量，值得进一步采用随机对照方法进行临床研究。
