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儿童变应性鼻炎与牙周支持组织病。

Allergic rhinitis and dental-supporting tissue diseases in children.

机构信息

Department of Chinese Medicine, China Medical University Hospital.

School of Chinese Medicine, China Medical University.

出版信息

Medicine (Baltimore). 2021 Feb 19;100(7):e24780. doi: 10.1097/MD.0000000000024780.

Abstract

The etiology of dental-supporting tissue diseases in children is multi factorial and not merely related to oral hygiene. Therefore, in the present study, we investigated the relationship between children <18 years old with allergic rhinitis (AR) and the risk of dental-supporting tissue diseases.Data from the National Health Insurance Research Database (NHIRD) of Taiwan were used to conduct a retrospective longitudinal cohort study. The study cohort comprised 378,160 patients with AR (AR group) and 378,160 patients without AR (non-AR group), who were selected through frequency matching based on age, sex, and the index year. The study patients were followed until dental-supporting tissue diseases occurrence, withdrawal from the National Health Insurance program, or December 31, 2013. Cox proportional hazards regression analysis was conducted to calculate the risk of dental-supporting tissue diseases in the AR group after adjustment for age, sex, and relative comorbidities.The adjusted HRs of periodontal, pulp, and periapical diseases in AR children were higher than those in the non-AR controls (1.51, 95% CI: 1.50 to 1.53; 1.06, 95% CI: 1.05 to 1.07, respectively). The AR to non-AR HRs of these inflammatory dental diseases were particularly higher in children <6 years old and in boys. The HRs of periodontal, pulp, and periapical diseases were greatest in those with >5 AR-related medical visits/year (5.57, 95% CI: 5.50 to 5.56; 4.06, 95% CI: 4.00 to 4.12, respectively).Children with AR had a greater risk of inflammatory dental-supporting tissue diseases, particularly those <6 years old with primary teeth, boys, and those with severe persistent AR.

摘要

儿童牙周支持组织疾病的病因是多因素的,不仅仅与口腔卫生有关。因此,在本研究中,我们调查了<18 岁患有过敏性鼻炎 (AR) 的儿童与牙周支持组织疾病风险之间的关系。

本研究使用了来自中国台湾地区全民健康保险研究数据库 (NHIRD) 的数据,进行了一项回顾性纵向队列研究。研究队列包括 378160 例 AR 患者(AR 组)和 378160 例非 AR 患者(非 AR 组),他们是通过年龄、性别和索引年的频率匹配选择的。研究患者随访至牙周支持组织疾病发生、退出全民健康保险计划或 2013 年 12 月 31 日。采用 Cox 比例风险回归分析,在调整年龄、性别和相对合并症后,计算 AR 组发生牙周、牙髓和根尖周疾病的风险。

在 AR 儿童中,牙周炎、牙髓炎和根尖周炎的调整后 HR 高于非 AR 对照组(1.51,95%CI:1.50 至 1.53;1.06,95%CI:1.05 至 1.07)。在<6 岁和男孩中,这些炎症性牙科疾病的 AR 与非 AR 的 HR 更高。在每年接受>5 次 AR 相关医疗就诊的患者中,牙周炎、牙髓炎和根尖周炎的 HR 最高(5.57,95%CI:5.50 至 5.56;4.06,95%CI:4.00 至 4.12)。

患有 AR 的儿童发生炎症性牙周支持组织疾病的风险更高,尤其是<6 岁有乳牙的儿童、男孩和患有严重持续性 AR 的儿童。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6a7/7899888/1ba87a8642c9/medi-100-e24780-g001.jpg

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