维生素 D 受体基因多态性（BsmI、TaqI、ApaI 和 FokI）与钙摄入量对年轻日本女性骨量的关系。

Relationship between vitamin D receptor gene polymorphisms (BsmI, TaqI, ApaI, and FokI) and calcium intake on bone mass in young Japanese women.

机构信息

Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, Saitama, Japan.

Department of Nutrition and Food Science, Graduate School of Humanities and Sciences, Ochanomizu University, Tokyo, Japan.

出版信息

BMC Womens Health. 2021 Feb 19;21(1):76. doi: 10.1186/s12905-021-01222-7.

DOI:10.1186/s12905-021-01222-7

PMID:33607983

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7893901/

Abstract

BACKGROUND

The high prevalence of low bone mass in young women in Japan has emerged as a serious health issue in recent years. Therefore, the aim of the present study was to reevaluate the relationship between genetic and dietary factors, as well as its influence on bone mass in young Japanese women, with particular emphasis on vitamin D receptor (VDR) gene polymorphisms and calcium intake.

METHODS

A total of 499 Japanese women aged 20-24 years were enrolled in the study. The bone mass of the calcaneus was assessed using the quantitative ultrasound method and expressed as the osteo sono-assessment index (OSI). VDR gene polymorphisms (BsmI, TaqI, ApaI, and FokI) were analyzed using DNA extracted from saliva. Calcium intake was assessed using the Food Frequency Questionnaire based on food groups (FFQg) and adjusted with the energy intake. Participants were divided into two groups based on the median calcium intake (250 mg/1000 kcal).

RESULTS

Consequently, bone mass was significantly different among the BsmI and TaqI genotypes after adjusting for body mass index (BMI) (p = 0.030 and 0.019, respectively). In addition, the BsmI AA and ApaI GT genotypes showed significant differences in bone mass between the calcium-intake groups, with low OSI in the low-calcium intake group and high OSI in the high-calcium intake group, respectively, even after adjusting for BMI (p = 0.020 and 0.038, respectively).

CONCLUSIONS

These findings may prove instrumental in developing a logical approach towards preventing bone loss in young Japanese women.

摘要

背景

近年来，日本年轻女性中普遍存在低骨量的问题，这已成为一个严重的健康问题。因此，本研究旨在重新评估遗传和饮食因素之间的关系及其对年轻日本女性骨量的影响，特别强调维生素 D 受体 (VDR) 基因多态性和钙摄入量。

方法

本研究共纳入 499 名 20-24 岁的日本女性。采用定量超声法评估跟骨骨量，并以骨声评估指数 (OSI) 表示。采用唾液提取的 DNA 分析 VDR 基因多态性（BsmI、TaqI、ApaI 和 FokI）。采用基于食物组的食物频率问卷（FFQg）评估钙摄入量，并根据能量摄入进行调整。根据钙摄入量的中位数（250mg/1000kcal）将参与者分为两组。

结果

在调整体重指数 (BMI) 后，BsmI 和 TaqI 基因型之间的骨量存在显著差异（p=0.030 和 0.019）。此外，BsmI AA 和 ApaI GT 基因型在钙摄入量组之间的骨量存在显著差异，低钙摄入量组的 OSI 较低，高钙摄入量组的 OSI 较高，即使在调整 BMI 后也是如此（p=0.020 和 0.038）。