• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

相似文献

1
Topical interferon alpha-2b for a giant ocular surface squamous neoplasia: 7 years of follow-up after complete remission.局部应用干扰素 α-2b 治疗巨大眼表鳞状细胞肿瘤:完全缓解后 7 年随访。
BMJ Case Rep. 2021 Feb 19;14(2):e240994. doi: 10.1136/bcr-2020-240994.
2
Interferon Alfa 2b for Ocular Surface Squamous Neoplasia: Factors Influencing the Treatment Response.干扰素α-2b治疗眼表鳞状上皮肿瘤:影响治疗反应的因素
Semin Ophthalmol. 2019;34(7-8):465-472. doi: 10.1080/08820538.2019.1648691. Epub 2019 Aug 1.
3
Management of Ocular Surface Squamous Neoplasia with Topical and Intralesional Interferon Alpha 2B in Mexicans.墨西哥人眼表鳞状上皮肿瘤的局部及瘤内注射α-2B干扰素治疗
Nepal J Ophthalmol. 2018 Jul;10(20):143-150. doi: 10.3126/nepjoph.v10i2.18574.
4
Interferon Alfa-2b for Pigmented Ocular Surface Squamous Neoplasia: A Report of 8 Lesions.干扰素 α-2b 治疗色素性眼表面鳞状上皮肿瘤:8 例病变报告。
Cornea. 2021 Feb 1;40(2):142-146. doi: 10.1097/ICO.0000000000002350.
5
Comparison of Topical 5-Fluorouracil and Interferon Alfa-2b as Primary Treatment Modalities for Ocular Surface Squamous Neoplasia.眼表面鳞状上皮肿瘤的局部 5-氟尿嘧啶和干扰素 Alfa-2b 作为主要治疗方式的比较。
Am J Ophthalmol. 2019 Mar;199:216-222. doi: 10.1016/j.ajo.2018.11.007. Epub 2018 Nov 22.
6
Long term study of topical interferon α-2b eye drops as primary treatment of ocular surface squamous neoplasia.眼局部用干扰素α-2b 滴眼剂作为眼表面鳞状上皮肿瘤的主要治疗方法的长期研究。
Ocul Surf. 2023 Apr;28:108-114. doi: 10.1016/j.jtos.2022.12.009. Epub 2022 Dec 30.
7
Changes in in vivo confocal microscopic findings of ocular surface squamous neoplasia during treatment with topical interferon alfa-2b.在眼表面鳞状上皮肿瘤治疗过程中活体共聚焦显微镜观察结果的变化。
Ocul Surf. 2018 Apr;16(2):235-241. doi: 10.1016/j.jtos.2017.12.003. Epub 2018 Jan 3.
8
Efficacy and safety of topical 5-fluorouracil in conjunctival intraepithelial neoplasia refractory to interferon alpha-2b.局部应用 5-氟尿嘧啶治疗对干扰素 α-2b 治疗抵抗的结膜上皮内瘤变的疗效和安全性。
J Oncol Pharm Pract. 2023 Jun;29(4):975-979. doi: 10.1177/10781552221125763. Epub 2022 Sep 21.
9
Usefulness of Topical Interferon Alpha-2b Eye Drop as an Adjunctive Therapy Following Surgical Resection in Ocular Surface Squamous Neoplasia.眼局部应用干扰素α-2b 在眼表面鳞状上皮肿瘤切除术后辅助治疗中的作用。
In Vivo. 2019 Nov-Dec;33(6):2211-2215. doi: 10.21873/invivo.11724.
10
Role of topical interferon alpha-2b in 'mitomycin-C-resistant' ocular surface squamous neoplasia: our preliminary findings.局部应用干扰素α-2b在“丝裂霉素C耐药”的眼表鳞状上皮肿瘤中的作用:我们的初步研究结果。
Int Ophthalmol. 2019 Feb;39(2):295-301. doi: 10.1007/s10792-017-0811-0. Epub 2018 Jan 23.

引用本文的文献

1
Clinical clues to the early diagnosis and management of ocular surface neoplasia following keratoplasty in xeroderma pigmentosa.原发性皮肤色素干皮病患者角膜移植术后眼表肿瘤的早期诊断和治疗的临床线索。
BMJ Case Rep. 2021 Aug 11;14(8):e244322. doi: 10.1136/bcr-2021-244322.

本文引用的文献

1
Update on pharmacotherapy for ocular surface squamous neoplasia.眼表鳞状上皮肿瘤药物治疗的最新进展
Eye Vis (Lond). 2019 Aug 12;6:24. doi: 10.1186/s40662-019-0150-5. eCollection 2019.
2
Update on Diagnosis and Management of Conjunctival Papilloma.结膜乳头状瘤的诊断与管理最新进展
Eye Vis (Lond). 2019 Jun 18;6:18. doi: 10.1186/s40662-019-0142-5. eCollection 2019.
3
Malignant transformation of a conjunctival keratoacanthoma requiring enucleation.一例需要眼球摘除的结膜角化棘皮瘤恶变。
Clin Ter. 2019 Mar-Apr;170(2):e81-e83. doi: 10.7417/CT.2019.2113.
4
A prospective study of the incidence, associations and outcomes of ocular surface squamous neoplasia in the United Kingdom.一项关于英国眼表鳞状上皮肿瘤的发病率、相关性和结局的前瞻性研究。
Eye (Lond). 2019 Feb;33(2):283-294. doi: 10.1038/s41433-018-0217-x. Epub 2018 Dec 28.
5
Conjunctival Tumors: Review of Clinical Features, Risks, Biomarkers, and Outcomes--The 2017 J. Donald M. Gass Lecture.结膜肿瘤:临床特征、风险、生物标志物及预后综述——2017年J. 唐纳德·M. 加斯讲座
Asia Pac J Ophthalmol (Phila). 2017 Mar-Apr;6(2):109-120. doi: 10.22608/APO.201710.
6
Recombinant interferon alpha 2b for ocular surface squamous neoplasia: An efficient and cost-effective treatment modality in Asian Indian patients.重组干扰素α-2b治疗眼表鳞状上皮肿瘤:亚洲印度患者的一种有效且具有成本效益的治疗方式。
Indian J Ophthalmol. 2016 Oct;64(10):702-709. doi: 10.4103/0301-4738.195010.
7
Interferon alpha-2b in giant ocular surface squamous neoplasia.干扰素α-2b治疗巨大眼表鳞状细胞癌
Indian J Ophthalmol. 2016 May;64(5):393-4. doi: 10.4103/0301-4738.185620.
8
Amelanotic Conjunctival Melanoma.无色素性结膜黑色素瘤
JAMA Ophthalmol. 2016 Jan;134(1):e153568. doi: 10.1001/jamaophthalmol.2015.3568. Epub 2016 Jan 14.
9
Amelanotic Melanoma Arising within Conjunctival Melanocytic Intraepithelial Neoplasia Sine Pigmento.结膜无色素性黑素细胞上皮内瘤内发生的无色素性黑色素瘤。
Ophthalmology. 2015 Nov;122(11):2178. doi: 10.1016/j.ophtha.2015.09.007.
10
Topical interferon alpha-2b for treatment of noninvasive ocular surface squamous neoplasia with 360° limbal involvement.局部应用干扰素α-2b治疗累及360°角膜缘的非侵袭性眼表鳞状上皮肿瘤。
J Ophthalmic Vis Res. 2014 Oct-Dec;9(4):423-6. doi: 10.4103/2008-322X.150811.

局部应用干扰素 α-2b 治疗巨大眼表鳞状细胞肿瘤:完全缓解后 7 年随访。

Topical interferon alpha-2b for a giant ocular surface squamous neoplasia: 7 years of follow-up after complete remission.

机构信息

Ophthalmology, Centro Oftalmologico Virgilio Galvis, Floridablanca, Santander, Colombia.

Ophthalmology, Universidad Autonoma de Bucaramanga, Bucaramanga, Santander, Colombia.

出版信息

BMJ Case Rep. 2021 Feb 19;14(2):e240994. doi: 10.1136/bcr-2020-240994.

DOI:10.1136/bcr-2020-240994
PMID:33608345
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7896608/
Abstract

A man with a history of blind eye due to trauma 22 years earlier consulted at 53 years of age with a large conjunctival neoplastic lesion, compromising almost the entire temporal limbus, and reaching a size of approximately 16 mm on its larger diameter, in the conjunctiva. Management was started with topical and subconjunctival chemotherapy (interferon alpha-2b) in order to perform immunoreduction, but a dramatic response with total disappearance of the lesion was observed. In the follow-up time period of more than 7 years, there were no signs of recurrence.

摘要

一位 53 岁男性,22 年前因外伤导致右眼失明,此次因大的结膜肿瘤性病变就诊,病变几乎累及整个颞侧角膜缘,最大直径约 16mm,位于结膜。为进行免疫抑制,首先给予局部和结膜下化疗(干扰素-α2b),但观察到病变完全消失,出现显著缓解。随访超过 7 年,未见复发迹象。