局部应用干扰素 α-2b 治疗巨大眼表鳞状细胞肿瘤：完全缓解后 7 年随访。
Topical interferon alpha-2b for a giant ocular surface squamous neoplasia: 7 years of follow-up after complete remission.
机构信息
Ophthalmology, Centro Oftalmologico Virgilio Galvis, Floridablanca, Santander, Colombia.
Ophthalmology, Universidad Autonoma de Bucaramanga, Bucaramanga, Santander, Colombia.
出版信息
BMJ Case Rep. 2021 Feb 19;14(2):e240994. doi: 10.1136/bcr-2020-240994.
Abstract
A man with a history of blind eye due to trauma 22 years earlier consulted at 53 years of age with a large conjunctival neoplastic lesion, compromising almost the entire temporal limbus, and reaching a size of approximately 16 mm on its larger diameter, in the conjunctiva. Management was started with topical and subconjunctival chemotherapy (interferon alpha-2b) in order to perform immunoreduction, but a dramatic response with total disappearance of the lesion was observed. In the follow-up time period of more than 7 years, there were no signs of recurrence.
摘要
一位 53 岁男性，22 年前因外伤导致右眼失明，此次因大的结膜肿瘤性病变就诊，病变几乎累及整个颞侧角膜缘，最大直径约 16mm，位于结膜。为进行免疫抑制，首先给予局部和结膜下化疗（干扰素-α2b），但观察到病变完全消失，出现显著缓解。随访超过 7 年，未见复发迹象。
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